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Toxins 2010, 2(11), 2606-2621;

Snake Venom Disintegrins and Cell Migration

Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP, 13565-905, Brazil
Author to whom correspondence should be addressed.
Received: 24 August 2010 / Revised: 15 October 2010 / Accepted: 18 October 2010 / Published: 29 October 2010
(This article belongs to the Special Issue Disintegrins: Structure-Function and Translational Potential)
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Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extracellular matrix components, thus playing a central role in cell migration. Integrin clustering at focal adhesions drives actin polymerization along the cell leading edge, resulting in polarity of cell movement. Therefore, small integrin-binding proteins such as the snake venom disintegrins that inhibit integrin-mediated cell adhesion are expected to inhibit cell migration. Here we review the current knowledge on disintegrin and disintegrin-like protein effects on cell migration and their potential use as pharmacological tools in anti-inflammatory therapy as well as in inhibition of metastatic invasion. View Full-Text
Keywords: cell migration; disintegrin; snake venom; ADAM; αvβ3 integrin cell migration; disintegrin; snake venom; ADAM; αvβ3 integrin

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Selistre-de-Araujo, H.S.; Pontes, C.L.S.; Montenegro, C.F.; Martin, A.C.B.M. Snake Venom Disintegrins and Cell Migration. Toxins 2010, 2, 2606-2621.

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