Next Article in Journal
Formulation and Safety Tests of a Wickerhamomyces anomalus–Based Product: Potential Use of Killer Toxins of a Mosquito Symbiotic Yeast to Limit Malaria Transmission
Next Article in Special Issue
Assessment of Human Exposure to Five Alternaria Mycotoxins in China by Biomonitoring Approach
Previous Article in Journal
The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study
Previous Article in Special Issue
Analysis of Aflatoxin Biomarkers in the Hair of Experimental Animals
Article

Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation

1
National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands
2
Norwegian Veterinary Institute (NVI), P.O. Box 64, 1431 Ås, Norway
3
Norwegian Institute of Public Health (NIPH), N-0213 Oslo, Norway
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(10), 675; https://doi.org/10.3390/toxins13100675
Received: 27 August 2021 / Accepted: 16 September 2021 / Published: 22 September 2021
(This article belongs to the Special Issue Human Biomonitoring and Risk Assessment of Mycotoxins)
The dietary exposure to the mycotoxin deoxynivalenol (DON) can be assessed by human biomonitoring (HBM). Here, we assessed the relation between dietary DON intake and the excretion of its major metabolite DON-15-glucuronide (DON15GlcA) through time, in an everyday situation. For 49 volunteers from the EuroMix biomonitoring study, the intake of DON from each meal was calculated and the excretion of DON and its metabolites was analyzed for each urine void collected separately throughout a 24-h period. The relation between DON and DON15GlcA was analyzed with a statistical model to assess the residence time and the excreted fraction of ingested DON as DON15GlcA (fabs_excr). Fabs_excr was treated as a random effect variable to address its heterogeneity in the population. The estimated time in which 97.5% of the ingested DON was excreted as DON15GlcA was 12.1 h, the elimination half-life was 4.0 h. Based on the estimated fabs_excr, the mean reversed dosimetry factor (RDF) of DON15GlcA was 2.28. This RDF can be used to calculate the amount of total DON intake in an everyday situation, based on the excreted amount of DON15GlcA. We show that urine samples collected over 24 h are the optimal design to study DON exposure by HBM. View Full-Text
Keywords: deoxynivalenol; deoxynivalenol-15-glucuronide; mycotoxin; human biomonitoring; dietary exposure; renal excretion; human study deoxynivalenol; deoxynivalenol-15-glucuronide; mycotoxin; human biomonitoring; dietary exposure; renal excretion; human study
Show Figures

Figure 1

MDPI and ACS Style

van den Brand, A.D.; Hoogenveen, R.; Mengelers, M.J.B.; Zeilmaker, M.; Eriksen, G.S.; Uhlig, S.; Brantsæter, A.L.; Dirven, H.A.A.M.; Husøy, T. Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation. Toxins 2021, 13, 675. https://doi.org/10.3390/toxins13100675

AMA Style

van den Brand AD, Hoogenveen R, Mengelers MJB, Zeilmaker M, Eriksen GS, Uhlig S, Brantsæter AL, Dirven HAAM, Husøy T. Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation. Toxins. 2021; 13(10):675. https://doi.org/10.3390/toxins13100675

Chicago/Turabian Style

van den Brand, Annick D., Rudolf Hoogenveen, Marcel J.B. Mengelers, Marco Zeilmaker, Gunnar S. Eriksen, Silvio Uhlig, Anne L. Brantsæter, Hubert A.A.M. Dirven, and Trine Husøy. 2021. "Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation" Toxins 13, no. 10: 675. https://doi.org/10.3390/toxins13100675

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop