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The Degradation of Deoxynivalenol by Using Electrochemical Oxidation with Graphite Electrodes and the Toxicity Assessment of Degradation Products

Key Laboratory of Biological Resources and Ecological Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China
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Toxins 2019, 11(8), 478; https://doi.org/10.3390/toxins11080478
Received: 2 July 2019 / Revised: 30 July 2019 / Accepted: 9 August 2019 / Published: 19 August 2019
Deoxynivalenol (DON) is a common mycotoxin, which is known to be extremely harmful to human and livestock health. In this study, DON was degraded by electrochemical oxidation (ECO) using a graphite electrode and NaCl as the supporting electrolyte. The graphite electrode is advantageous due to its electrocatalytic activity, reusability, and security. The degradation process can be expressed by first-order kinetics. Approximately 86.4% of DON can be degraded within 30 min at a potential of 0.5 V. The degradation rate reached 93.2% within 30 min, when 0.5 V potential was used for electrocatalyzing a 10 mg/L DON solution. The degradation rate of DON in contaminated wet distiller’s grain with solubles (WDGS) was 86.37% in 60 min. Moreover, results from the cell counting kit-8 (CCK-8) and 4,6-diamidino-2-phenylindole dihydrochloride (DAPI) staining assay indicated that ECO reduced the DON-induced cytotoxicity and apoptotic bodies in a gastric epithelial cell line (GES-1) compared to the DON-treated group. These findings provide new insights into the application of ECO techniques for degrading mycotoxins, preventing food contamination, and assessing DON-related hazards. View Full-Text
Keywords: deoxynivalenol; electrochemical oxidation degradation; graphite electrode; cell toxicity; wet distiller’s grain with solubles (WDGS) deoxynivalenol; electrochemical oxidation degradation; graphite electrode; cell toxicity; wet distiller’s grain with solubles (WDGS)
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Xiong, S.; Li, X.; Zhao, C.; Gao, J.; Yuan, W.; Zhang, J. The Degradation of Deoxynivalenol by Using Electrochemical Oxidation with Graphite Electrodes and the Toxicity Assessment of Degradation Products. Toxins 2019, 11, 478.

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