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Open AccessArticle

Identification and Evaluations of Novel Insecticidal Proteins from Plants of the Class Polypodiopsida for Crop Protection against Key Lepidopteran Pests

1
Corteva Agriscience, Hayward, CA 94545, USA
2
Corteva Agriscience, Johnston, IA 50131, USA
*
Author to whom correspondence should be addressed.
Present address: Department of Biology, University of British Columbia Okanagan, 3187 University Way, Kelowna, B.C. V1V 1V7, Canada.
Present address: AgBiome Inc., 104 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA.
§
Present address: Jackson ImmunoResearch Inc. 872 W Baltimore Pike, West Grove, PA 19390, USA.
Present address: Syngenta, 9 Davis Drive, Research Triangle Park, NC 27709, USA.
Toxins 2019, 11(7), 383; https://doi.org/10.3390/toxins11070383
Received: 1 May 2019 / Revised: 21 June 2019 / Accepted: 22 June 2019 / Published: 1 July 2019
Various lepidopteran insects are responsible for major crop losses worldwide. Although crop plant varieties developed to express Bacillus thuringiensis (Bt) proteins are effective at controlling damage from key lepidopteran pests, some insect populations have evolved to be insensitive to certain Bt proteins. Here, we report the discovery of a family of homologous proteins, two of which we have designated IPD083Aa and IPD083Cb, which are from Adiantum spp. Both proteins share no known peptide domains, sequence motifs, or signatures with other proteins. Transgenic soybean or corn plants expressing either IPD083Aa or IPD083Cb, respectively, show protection from feeding damage by several key pests under field conditions. The results from comparative studies with major Bt proteins currently deployed in transgenic crops indicate that the IPD083 proteins function by binding to different target sites. These results indicate that IPD083Aa and IPD083Cb can serve as alternatives to traditional Bt-based insect control traits with potential to counter insect resistance to Bt proteins. View Full-Text
Keywords: plant protein; insecticidal; genetically modified; lepidopteran; resistance management plant protein; insecticidal; genetically modified; lepidopteran; resistance management
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Liu, L.; Schepers, E.; Lum, A.; Rice, J.; Yalpani, N.; Gerber, R.; Jiménez-Juárez, N.; Haile, F.; Pascual, A.; Barry, J.; Qi, X.; Kassa, A.; Heckert, M.J.; Xie, W.; Ding, C.; Oral, J.; Nguyen, M.; Le, J.; Procyk, L.; Diehn, S.H.; Crane, V.C.; Damude, H.; Pilcher, C.; Booth, R.; Liu, L.; Zhu, G.; Nowatzki, T.M.; Nelson, M.E.; Lu, A.L.; Wu, G. Identification and Evaluations of Novel Insecticidal Proteins from Plants of the Class Polypodiopsida for Crop Protection against Key Lepidopteran Pests. Toxins 2019, 11, 383.

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