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Toxins 2019, 11(4), 196; https://doi.org/10.3390/toxins11040196

Detection of Five Mycotoxins in Different Food Matrices in the Malaysian Market by Using Validated Liquid Chromatography Electrospray Ionization Triple Quadrupole Mass Spectrometry

1
Department of Chemistry, Faculty of Science, University of Mala, Kuala Lumpur 50603, Malaysia
2
Arab Centre for Desertification and Development of Saharian Societies, Murzuk, Libya
*
Authors to whom correspondence should be addressed.
Received: 5 March 2019 / Revised: 28 March 2019 / Accepted: 29 March 2019 / Published: 31 March 2019
(This article belongs to the Section Mycotoxins)
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Abstract

Mycotoxins are common food contaminants which cause poisoning and severe health risks to humans and animals. The present study applied chemometric approach in liquid chromatography-tandem mass spectrometry (LC-MS/MS) optimization for simultaneous determination of mycotoxins, i.e., aflatoxins B1, B2, G1, and G2, and ochratoxin A. The validated quick, easy, cheap, effective, rugged, and safe (QuEChERS)-LC-MS/MS method was used to study the occurrence of mycotoxins in 120 food matrices. The recovery ranges from 81.94% to 101.67% with relative standard deviation (RSD) lesser than 11%. Through the developed method, aflatoxins were detected in raisin, pistachio, peanut, wheat flour, spice, and chili samples with concentration ranges from 0.45 to 16.93 µg/kg. Trace concentration of ochratoxin A was found in wheat flour and peanut samples which ranged from 1.2 to 3.53 µg/kg. Some of the tested food samples contained mycotoxins of above the European legal maximum limit. View Full-Text
Keywords: mycotoxins; aflatoxin; ochratoxin; Plackett–Burman design; Box–Behnken design; QuEChERS; LC-MS/MS mycotoxins; aflatoxin; ochratoxin; Plackett–Burman design; Box–Behnken design; QuEChERS; LC-MS/MS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Alsharif, A.M.A.; Choo, Y.-M.; Tan, G.-H. Detection of Five Mycotoxins in Different Food Matrices in the Malaysian Market by Using Validated Liquid Chromatography Electrospray Ionization Triple Quadrupole Mass Spectrometry. Toxins 2019, 11, 196.

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