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Intracellular Trafficking and Translocation of Pertussis Toxin
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Pertussis Toxin: A Key Component in Pertussis Vaccines?

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
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Toxins 2019, 11(10), 557; https://doi.org/10.3390/toxins11100557
Received: 27 August 2019 / Revised: 18 September 2019 / Accepted: 19 September 2019 / Published: 21 September 2019
(This article belongs to the Special Issue Pertussis Toxin)
B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The ongoing resurgence in pertussis incidence in high income countries is likely due to faster waning of immunity and increased asymptomatic colonization in individuals vaccinated with acellular pertussis (aP) vaccine relative whole-cell pertussis (wP)-vaccinated individuals. This has renewed interest in developing more effective vaccines and treatments and, in support of these efforts, defining pertussis vaccine correlates of protection and the role of vaccine antigens and toxins in disease. Pertussis and its toxins have been investigated by scientists for over a century, yet we still do not have a clear understanding of how pertussis toxin (PT) contributes to disease symptomology or how anti-PT immune responses confer protection. This review covers PT’s role in disease and evidence for its protective role in vaccines. Clinical data suggest that PT is a defining and essential toxin for B. pertussis pathogenesis and, when formulated into a vaccine, can prevent disease. Additional studies are required to further elucidate the role of PT in disease and vaccine-mediated protection, to inform the development of more effective treatments and vaccines. View Full-Text
Keywords: Bordetella pertussis; bacterial infection; immunization; pertussis toxin; whooping cough; pertussis; pertussis vaccine Bordetella pertussis; bacterial infection; immunization; pertussis toxin; whooping cough; pertussis; pertussis vaccine
MDPI and ACS Style

Gregg, K.A.; Merkel, T.J. Pertussis Toxin: A Key Component in Pertussis Vaccines? Toxins 2019, 11, 557.

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