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Toxins 2018, 10(6), 218;

The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function

MP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, France
Department of Pharmacy, Amiens University Medical Center, 80000 Amiens, France
DRCI, Amiens University Hospital, 80054 Amiens, France
Laboratory of Biochemistry, Amiens University Hospital, 80054 Amiens, France
Ambroise Paré University Hospital, Division of Nephrology, APHP, 92100 Boulogne-Billancourt/Paris, France
INSERM U1018, Team 5, CESP, UVSQ, Paris-Saclay University, 94800 Villejuif, France
Author to whom correspondence should be addressed.
Received: 30 April 2018 / Revised: 26 May 2018 / Accepted: 27 May 2018 / Published: 29 May 2018
(This article belongs to the Special Issue Uremia and Cardiovascular Disease)
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Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs’ physiological functions. Chronic, low-grade inflammation and oxidative stress—hallmarks of CKD—are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling. View Full-Text
Keywords: chronic kidney disease; uremic toxins; vascular smooth muscle cells chronic kidney disease; uremic toxins; vascular smooth muscle cells

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Hénaut, L.; Mary, A.; Chillon, J.-M.; Kamel, S.; Massy, Z.A. The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function. Toxins 2018, 10, 218.

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