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Toxins 2018, 10(2), 52; https://doi.org/10.3390/toxins10020052

Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment—An In Silico Perspective

Department of Food and Drug, University of Parma, 43124 Parma, Italy
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Received: 26 November 2017 / Revised: 16 January 2018 / Accepted: 20 January 2018 / Published: 23 January 2018
(This article belongs to the Section Mycotoxins)
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Abstract

Mycotoxins severely threaten the health of humans and animals. For this reason, many countries have enforced regulations and recommendations to reduce the dietary exposure. However, even though regulatory actions must be based on solid scientific knowledge, many aspects of their toxicological activity are still poorly understood. In particular, deepening knowledge on the primal molecular events triggering the toxic stimulus may be relevant to better understand the mechanisms of action of mycotoxins. The present work presents the use of in silico approaches in studying the mycotoxins toxicodynamics, and discusses how they may contribute in widening the background of knowledge. A particular emphasis has been posed on the methods accounting the molecular initiating events of toxic action. In more details, the key concepts and challenges of mycotoxins toxicology have been introduced. Then, topical case studies have been presented and some possible practical implementations of studying mycotoxins toxicodynamics have been discussed. View Full-Text
Keywords: mycotoxins; toxicology; in silico molecular modeling; toxicodynamic; risk assessment computational toxicology; mechanism of action mycotoxins; toxicology; in silico molecular modeling; toxicodynamic; risk assessment computational toxicology; mechanism of action
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Dellafiora, L.; Dall’Asta, C.; Galaverna, G. Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment—An In Silico Perspective. Toxins 2018, 10, 52.

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