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Sugars, Sweet Taste Receptors, and Brain Responses

by Allen A. Lee 1 and Chung Owyang 2,*
1500 East Medical Center Drive, Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109-5362, USA
3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109-5362, USA
Author to whom correspondence should be addressed.
Nutrients 2017, 9(7), 653;
Received: 10 April 2017 / Revised: 20 June 2017 / Accepted: 21 June 2017 / Published: 24 June 2017
Sweet taste receptors are composed of a heterodimer of taste 1 receptor member 2 (T1R2) and taste 1 receptor member 3 (T1R3). Accumulating evidence shows that sweet taste receptors are ubiquitous throughout the body, including in the gastrointestinal tract as well as the hypothalamus. These sweet taste receptors are heavily involved in nutrient sensing, monitoring changes in energy stores, and triggering metabolic and behavioral responses to maintain energy balance. Not surprisingly, these pathways are heavily regulated by external and internal factors. Dysfunction in one or more of these pathways may be important in the pathogenesis of common diseases, such as obesity and type 2 diabetes mellitus. View Full-Text
Keywords: sweet taste receptors; glucose sensing; nutrient sensing; leptin; hypothalamus sweet taste receptors; glucose sensing; nutrient sensing; leptin; hypothalamus
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Lee, A.A.; Owyang, C. Sugars, Sweet Taste Receptors, and Brain Responses. Nutrients 2017, 9, 653.

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