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Nutrients 2017, 9(5), 513;

Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective

Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
Nature’s Bounty Co., Ronkonkoma, NY 11779, USA
Author to whom correspondence should be addressed.
Received: 30 March 2017 / Revised: 12 May 2017 / Accepted: 15 May 2017 / Published: 18 May 2017
(This article belongs to the Special Issue Immunology: Nutrition, Exercise and Adiposity Relationships)
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This review describes effective and ineffective immunonutrition support strategies for the athlete, with a focus on the benefits of carbohydrates and polyphenols as determined from metabolomics-based procedures. Athletes experience regular cycles of physiological stress accompanied by transient inflammation, oxidative stress, and immune perturbations, and there are increasing data indicating that these are sensitive to nutritional influences. The most effective nutritional countermeasures, especially when considered from a metabolomics perspective, include acute and chronic increases in dietary carbohydrate and polyphenols. Carbohydrate supplementation reduces post-exercise stress hormone levels, inflammation, and fatty acid mobilization and oxidation. Ingestion of fruits high in carbohydrates, polyphenols, and metabolites effectively supports performance, with added benefits including enhancement of oxidative and anti-viral capacity through fruit metabolites, and increased plasma levels of gut-derived phenolics. Metabolomics and lipidomics data indicate that intensive and prolonged exercise is associated with extensive lipid mobilization and oxidation, including many components of the linoleic acid conversion pathway and related oxidized derivatives called oxylipins. Many of the oxylipins are elevated with increased adiposity, and although low in resting athletes, rise to high levels during recovery. Future targeted lipidomics-based studies will help discover whether n-3-polyunsaturated fatty acid (n-3-PUFA) supplementation enhances inflammation resolution in athletes post-exercise. View Full-Text
Keywords: immune function; sports nutrition; immunonutrition; immunometabolism; metabolomics immune function; sports nutrition; immunonutrition; immunometabolism; metabolomics

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Nieman, D.C.; Mitmesser, S.H. Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective. Nutrients 2017, 9, 513.

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