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Open AccessReview

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

1
Center for Nutraceutical and Dietary Supplement Research, School of Health Studies, The University of Memphis, Memphis, TN 38152, USA
2
Bergstrom Nutrition, Vancouver, WA 98660, USA
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(3), 290; https://doi.org/10.3390/nu9030290
Received: 19 December 2016 / Revised: 22 February 2017 / Accepted: 13 March 2017 / Published: 16 March 2017
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal models, as well as in human clinical trials and experiments. A variety of health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity. Initial evidence is available regarding the dose of MSM needed to provide benefit, although additional work is underway to determine the precise dose and time course of treatment needed to provide optimal benefits. As a Generally Recognized As Safe (GRAS) approved substance, MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects. This review provides an overview of MSM, with details regarding its common uses and applications as a dietary supplement, as well as its safety for consumption. View Full-Text
Keywords: methylsulfonylmethane; MSM; dimethyl sulfone; inflammation; joint pain methylsulfonylmethane; MSM; dimethyl sulfone; inflammation; joint pain
MDPI and ACS Style

Butawan, M.; Benjamin, R.L.; Bloomer, R.J. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients 2017, 9, 290.

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