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Open AccessArticle

Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice

by Jung-Soo Bae 1,2,3,†, Mira Han 1,2,3,†, Hee Soon Shin 4,5, Dong-Hwa Shon 4,5, Soon-Tae Lee 6, Chang-Yup Shin 1,2,3, Yuri Lee 1,2,3, Dong Hun Lee 1,2,3,* and Jin Ho Chung 1,2,3,7,*
1
Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea
2
Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea
3
Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea
4
Korea Food Research Institute, Seongnam-si, Kyeonggi-do 13539, Korea
5
Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Korea
6
Department of Neurology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea
7
SNU Institute on Aging, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(11), 679; https://doi.org/10.3390/nu8110679
Received: 21 August 2016 / Revised: 6 October 2016 / Accepted: 20 October 2016 / Published: 26 October 2016
A decrease in adult neurogenesis is associated with the aging process, and this decrease is closely related to memory impairment. Tomato (Lycopersicon esculentum) is a fruit with diverse bioactive nutrients that is consumed worldwide. In this study, we investigated the cognition-enhancing effect of tomato ethanolic extracts (TEE) in aged mice. Six weeks of oral TEE administration in 12-month-old aged mice significantly increased their exploration time of novel objects when compared to vehicle-treated mice. The TEE supplement increased doublecortin (DCX)-positive cells and postsynaptic density-95 (PSD95) expression in mice hippocampus. Moreover, we found an increased expression of brain-derived neurotrophic factor (BDNF) and subsequently-activated extracellular-signal-regulated kinase (ERK)/cAMP response element binding (CREB) signaling pathway in the TEE-supplemented mice hippocampus. In conclusion, the oral administration of TEE exhibits a cognition-enhancing effect, and the putative underlying mechanism is the induction of BDNF signaling-mediated proliferation and synapse formation in the hippocampus. These findings indicate that TEE could be a candidate for treatment of age-related memory impairment and neurodegenerative disorders. View Full-Text
Keywords: aging; brain-derived neurotrophic factor; hippocampus; memory function; neurogenesis; tomato ethanolic extracts aging; brain-derived neurotrophic factor; hippocampus; memory function; neurogenesis; tomato ethanolic extracts
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Bae, J.-S.; Han, M.; Shin, H.S.; Shon, D.-H.; Lee, S.-T.; Shin, C.-Y.; Lee, Y.; Lee, D.H.; Chung, J.H. Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice. Nutrients 2016, 8, 679.

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