Next Article in Journal
Concomitant Use of Dietary Supplements and Medicines in Patients due to Miscommunication with Physicians in Japan
Next Article in Special Issue
Phylum Level Change in the Cecal and Fecal Gut Communities of Rats Fed Diets Containing Different Fermentable Substrates Supports a Role for Nitrogen as a Factor Contributing to Community Structure
Previous Article in Journal / Special Issue
The Queuine Micronutrient: Charting a Course from Microbe to Man
Open AccessReview

The Role of Microbial Amino Acid Metabolism in Host Metabolism

Department of Surgery, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(4), 2930-2946; https://doi.org/10.3390/nu7042930
Received: 20 February 2015 / Revised: 21 March 2015 / Accepted: 1 April 2015 / Published: 16 April 2015
(This article belongs to the Special Issue Microbiome and Human Health)
Disruptions in gut microbiota composition and function are increasingly implicated in the pathogenesis of obesity, insulin resistance, and type 2 diabetes mellitus. The functional output of the gut microbiota, including short-chain fatty acids and amino acids, are thought to be important modulators underlying the development of these disorders. Gut bacteria can alter the bioavailability of amino acids by utilization of several amino acids originating from both alimentary and endogenous proteins. In turn, gut bacteria also provide amino acids to the host. This could have significant implications in the context of insulin resistance and type 2 diabetes mellitus, conditions associated with elevated systemic concentrations of certain amino acids, in particular the aromatic and branched-chain amino acids. Moreover, several amino acids released by gut bacteria can serve as precursors for the synthesis of short-chain fatty acids, which also play a role in the development of obesity. In this review, we aim to compile the available evidence on the contribution of microbial amino acids to host amino acid homeostasis, and to assess the role of the gut microbiota as a determinant of amino acid and short-chain fatty acid perturbations in human obesity and type 2 diabetes mellitus. View Full-Text
Keywords: amino acids; short-chain fatty acids; gut microbiota; obesity; type 2 diabetes mellitus amino acids; short-chain fatty acids; gut microbiota; obesity; type 2 diabetes mellitus
MDPI and ACS Style

Neis, E.P.J.G.; Dejong, C.H.C.; Rensen, S.S. The Role of Microbial Amino Acid Metabolism in Host Metabolism. Nutrients 2015, 7, 2930-2946. https://doi.org/10.3390/nu7042930

AMA Style

Neis EPJG, Dejong CHC, Rensen SS. The Role of Microbial Amino Acid Metabolism in Host Metabolism. Nutrients. 2015; 7(4):2930-2946. https://doi.org/10.3390/nu7042930

Chicago/Turabian Style

Neis, Evelien P.J.G.; Dejong, Cornelis H.C.; Rensen, Sander S. 2015. "The Role of Microbial Amino Acid Metabolism in Host Metabolism" Nutrients 7, no. 4: 2930-2946. https://doi.org/10.3390/nu7042930

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop