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Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

1
Department of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, Taiwan
2
Department of Science, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(4), 2850-2865; https://doi.org/10.3390/nu7042850
Received: 26 January 2015 / Revised: 15 March 2015 / Accepted: 25 March 2015 / Published: 15 April 2015
Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction. View Full-Text
Keywords: resveratrol; methylglyoxal; nuclear factor erythroid 2-related factor 2; retinoic acid; diabetes resveratrol; methylglyoxal; nuclear factor erythroid 2-related factor 2; retinoic acid; diabetes
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Cheng, A.-S.; Cheng, Y.-H.; Lee, C.-Y.; Chung, C.-Y.; Chang, W.-C. Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo. Nutrients 2015, 7, 2850-2865.

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