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Effect of Whey Supplementation on Circulating C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

1
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China
2
Key Laboratory of Radiation Biology, School of Radiation Medicine and Protection, Soochow University, 199 Renai Road, Suzhou 215123, China
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Suzhou Health College, 28 Kehua Road, Suzhou 215009, China
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Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, 199 Renai Road, Suzhou 215123, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(2), 1131-1143; https://doi.org/10.3390/nu7021131
Received: 24 October 2014 / Accepted: 2 February 2015 / Published: 9 February 2015
Whey supplementation is beneficial for human health, possibly by reducing the circulating C-reactive protein (CRP) level, a sensitive marker of inflammation. Thus, a meta-analysis of randomized controlled trials was conducted to evaluate their relationship. A systematic literature search was conducted in July, 2014, to identify eligible studies. Either a fixed-effects model or a random-effects model was used to calculate pooled effects. The meta-analysis results of nine trials showed a slight, but no significant, reduction of 0.42 mg/L (95% CI −0.96, 0.13) in CRP level with the supplementation of whey protein and its derivates. Relatively high heterogeneity across studies was observed. Subgroup analyses showed that whey significantly lowered CRP by 0.72 mg/L (95% CI −0.97, −0.47) among trials with a daily whey dose ≥20 g/day and by 0.67 mg/L (95% CI −1.21, −0.14) among trials with baseline CRP ≥3 mg/L. Meta-regression analysis revealed that the baseline CRP level was a potential effect modifier of whey supplementation in reducing CRP. In conclusion, our meta-analysis did not find sufficient evidence that whey and its derivates elicited a beneficial effect in reducing circulating CRP. However, they may significantly reduce CRP among participants with highly supplemental doses or increased baseline CRP levels. View Full-Text
Keywords: whey protein; C-reactive protein; randomized controlled trial; meta-analysisv whey protein; C-reactive protein; randomized controlled trial; meta-analysisv
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Zhou, L.-M.; Xu, J.-Y.; Rao, C.-P.; Han, S.; Wan, Z.; Qin, L.-Q. Effect of Whey Supplementation on Circulating C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2015, 7, 1131-1143.

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