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Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs

Metabolic Bone Disease Research Group, School of Nursing and Occupational Therapy, University of Extremadura, Cáceres 10003, Spain
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These authors contributed equally to this work.
Nutrients 2015, 7(12), 9908-9917; https://doi.org/10.3390/nu7125517
Received: 12 October 2015 / Revised: 12 November 2015 / Accepted: 23 November 2015 / Published: 1 December 2015
We aimed to investigate and compare the effects of chronic antiepileptic therapy on bone health in pediatric patients using quantitative ultrasound of the phalanges (QUS) and controlling for potential confounding factors, particularly nutrient intake. The amplitude-dependent speed of sound (Ad-SoS) was measured in 33 epileptic children and 32 healthy children aged 6.5 ± 3.1 and 6.3 ± 1.1 (mean ± SD) years, respectively. There were no significant differences in the demographics such as age, weight and height between epileptic children and the control group children. None of the children in the epileptic or the treatment group were found to have a vitamin D deficiency. There were no significant differences in laboratory tests between groups. Lower QUS figures were found in the epileptic children (p = 0.001). After further adjustment for potential confounders such age, height, weight, calcium intake, vitamin D intake, physical activity and sex, the differences remained significant (p < 0.001). After further classification of the participants based on the tertile of calcium intake, no significant differences were found between patients and healthy controls in the greatest tertile of calcium intake (p = 0.217). We conclude that anticonvulsant therapy using valproate may lead to low bone mass in children and that an adequate intake of calcium might counteract such deleterious effects. View Full-Text
Keywords: antiepileptic therapy; bone health; quantitative ultrasound; children antiepileptic therapy; bone health; quantitative ultrasound; children
MDPI and ACS Style

Vera, V.; Moran, J.M.; Barros, P.; Canal-Macias, M.L.; Guerrero-Bonmatty, R.; Costa-Fernandez, C.; Lavado-Garcia, J.M.; Roncero-Martin, R.; Pedrera-Zamorano, J.D. Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs. Nutrients 2015, 7, 9908-9917.

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