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Open AccessArticle

Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice

1
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
2
Laboratory Animal Research Center, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
3
Wellness R&D Center, Univera, Inc., Seoul 05014, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(12), 10480-10490; https://doi.org/10.3390/nu7125544
Received: 13 October 2015 / Revised: 5 December 2015 / Accepted: 10 December 2015 / Published: 15 December 2015
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Obesity, which is characterized by excessive fat accumulation, is associated with several pathological disorders, including metabolic diseases. In this study, the anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet (HFD)-induced obese mice at the doses of 10 and 30 mg/kg for six week. The body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. In addition, fat accumulation in epididymal adipose tissue and liver was dramatically decreased in the HFD + DPG groups. The food efficiency ratios of the HFD + DPG groups were also lower compared to the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD + DPG groups. Further studies demonstrate that DPG efficiently reduces lipogenic genes by regulation of transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and hormones, such as leptin and adiponection. DPG also regulates acetyl-CoA carboxylase (ACC) and hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) by AMP-activated protein kinase (AMPK) activation. Taken together, DPG is beneficial for the regulation of obesity, especially resulting from high fat intake. View Full-Text
Keywords: 6,8-Diprenylgenistein (DPG); Cudrania tricuspidata; high-fat diet-induced obesity; lipid profile; AMPK 6,8-Diprenylgenistein (DPG); Cudrania tricuspidata; high-fat diet-induced obesity; lipid profile; AMPK
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Jo, Y.H.; Choi, K.-M.; Liu, Q.; Kim, S.B.; Ji, H.-J.; Kim, M.; Shin, S.-K.; Do, S.-G.; Shin, E.; Jung, G.; Yoo, H.-S.; Hwang, B.Y.; Lee, M.K. Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice. Nutrients 2015, 7, 10480-10490.

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