Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression

Paidi, Maya D.; Schjoldager, Janne G.; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille

doi:10.3390/nu6051809

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Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression

Maya D. Paidi

Janne G. Schjoldager

Jens Lykkesfeldt

and

Pernille Tveden-Nyborg

Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 1870, Denmark

Author to whom correspondence should be addressed.

Nutrients 2014, 6(5), 1809-1822; https://doi.org/10.3390/nu6051809

Received: 18 March 2014 / Revised: 3 April 2014 / Accepted: 17 April 2014 / Published: 29 April 2014

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Abstract

Vitamin C (VitC) has several roles in the brain acting both as a specific and non-specific antioxidant. The brain upholds a very high VitC concentration and is able to preferentially retain VitC even during deficiency. The accumulation of brain VitC levels much higher than in blood is primarily achieved by the sodium dependent VitC transporter (SVCT2). This study investigated the effects of chronic pre-and postnatal VitC deficiency as well as the effects of postnatal VitC repletion, on brain SVCT2 expression and markers of oxidative stress in young guinea pigs. Biochemical analyses demonstrated significantly decreased total VitC and an increased percentage of dehydroascorbic acid, as well as increased lipid oxidation (malondialdehyde), in the brains of VitC deficient animals (p < 0.0001) compared to controls. VitC repleted animals were not significantly different from controls. No significant changes were detected in either gene or protein expression of SVCT2 between groups or brain regions. In conclusion, chronic pre-and postnatal VitC deficiency increased brain redox imbalance but did not increase SVCT2 expression. Our findings show potential implications for VitC deficiency induced negative effects of redox imbalance in the brain and provide novel insight to the regulation of VitC in the brain during deficiency. View Full-Text

Keywords: vitamin C deficiency; SVCT2; redox imbalance; oxidative stress

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Paidi, M.D.; Schjoldager, J.G.; Lykkesfeldt, J.; Tveden-Nyborg, P. Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression. Nutrients 2014, 6, 1809-1822. https://doi.org/10.3390/nu6051809

AMA Style

Paidi MD, Schjoldager JG, Lykkesfeldt J, Tveden-Nyborg P. Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression. Nutrients. 2014; 6(5):1809-1822. https://doi.org/10.3390/nu6051809

Chicago/Turabian Style

Paidi, Maya D., Janne G. Schjoldager, Jens Lykkesfeldt, and Pernille Tveden-Nyborg. 2014. "Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression" Nutrients 6, no. 5: 1809-1822. https://doi.org/10.3390/nu6051809

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Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression

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