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The Effects of α-Tocopherol on Bone: A Double-Edged Sword?

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
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Nutrients 2014, 6(4), 1424-1441; https://doi.org/10.3390/nu6041424
Received: 2 January 2014 / Revised: 22 February 2014 / Accepted: 28 February 2014 / Published: 10 April 2014
(This article belongs to the Special Issue Vitamin E Nutrition and Metabolism)
Recent studies have found conflicting evidence on the role of α-tocopherol (αTF) on bone health. This nonsystematic review aimed to summarize the current evidence on the effects of αTF on bone health from cell culture, animal, and human studies in order to clarify the role of αTF on bone health. Our review found that αTF exerted beneficial, harmful or null effects on bone formation cells. Animal studies generally showed positive effects of αTF supplementation on bone in various models of osteoporosis. However, high-dose αTF was possibly detrimental to bone in normal animals. Human studies mostly demonstrated a positive relationship between αTF, as assessed using high performance liquid chromatography and/or dietary questionnaire, and bone health, as assessed using bone mineral density and/or fracture incidence. Three possible reasons high dosage of αTF can be detrimental to bone include its interference with Vitamin K function on bone, the blocking of the entry of other Vitamin E isomers beneficial to bone, and the role of αTF as a prooxidant. However, these adverse effects have not been shown in human studies. In conclusion, αTF may have a dual role in bone health, whereby in the appropriate doses it is beneficial but in high doses it may be harmful to bone. View Full-Text
Keywords: α-tocopherol; bone; fracture; osteoporosis; vitamin E α-tocopherol; bone; fracture; osteoporosis; vitamin E
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Chin, K.-Y.; Ima-Nirwana, S. The Effects of α-Tocopherol on Bone: A Double-Edged Sword? Nutrients 2014, 6, 1424-1441.

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