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The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction

Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
Department of Pharmacy, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
Author to whom correspondence should be addressed.
Nutrients 2014, 6(3), 1236-1250;
Received: 2 January 2014 / Revised: 7 March 2014 / Accepted: 14 March 2014 / Published: 24 March 2014
A hereditary postprandial hypertriglyceridemic rabbit (PHT rabbit) is a new dyslipidemic model showing remarkably high plasma triglycerides with only limited elevation of plasma total cholesterol. In PHT rabbits, plasma triglyceride was markedly elevated postprandially compared with healthy Japanese white (JW) rabbits. In physiological experiments, the ring preparation of the thoracic aorta was suspended in an organ bath filled with modified Krebs-Henseleit solution, and the developed tension was recorded. Endothelial function was evaluated by acetylcholine-induced vasorelaxation in each preparation with intact endothelium. The acetylcholine-induced endothelium-dependent relaxation was diminished in PHT compared with JW rabbits, suggesting endothelial dysfunction in PHT rabbits. Histological examination was carried out in adipose tissue, liver and aorta. They were fixed in formaldehyde and embedded in paraffin. The tissues were sliced (4 μm) and stained using hematoxylin-eosin solution. In the adipose tissue, the visceral fat accumulated, and the size of adipose cells was enlarged in PHT rabbits. The liver of the PHT rabbit was fatty and degenerated. In aorta, increased intimal thickness was observed, suggesting the progression of atherosclerosis in the PHT rabbit. This study suggests the important role of postprandial hypertriglyceridemia in atherosclerosis. By using PHT rabbits, the effects of hypertriglyceridemia on health and diseases could be evaluated precisely. View Full-Text
Keywords: hypertriglyceridemia; atherosclerosis; visceral fat; liver; aorta; endothelium hypertriglyceridemia; atherosclerosis; visceral fat; liver; aorta; endothelium
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Matsumoto, S.; Gotoh, N.; Hishinuma, S.; Abe, Y.; Shimizu, Y.; Katano, Y.; Ishihata, A. The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction. Nutrients 2014, 6, 1236-1250.

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