Next Article in Journal
Comparative Study on the Hypoglycemic and Antioxidative Effects of Fermented Paste (Doenjang) Prepared from Soybean and Brown Rice Mixed with Rice Bran or Red Ginseng Marc in Mice Fed with High Fat Diet
Next Article in Special Issue
Obesity: Pathophysiology and Intervention
Previous Article in Journal / Special Issue
The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review

Animal Models of Compulsive Eating Behavior

Dipartimento di Psicologia and Centro "Daniel Bovet", Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00181 Roma, Italy
IRCCS Fondazione Santa Lucia, via del Fosso di Fiorano 64, 00143 Roma, Italy
Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, University of L'Aquila, via Vetoio (Coppito 2) Coppito, 67010 L'Aquila, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2014, 6(10), 4591-4609;
Received: 22 August 2014 / Revised: 7 October 2014 / Accepted: 10 October 2014 / Published: 22 October 2014
(This article belongs to the Special Issue Food Addiction)
Eating disorders are multifactorial conditions that can involve a combination of genetic, metabolic, environmental, and behavioral factors. Studies in humans and laboratory animals show that eating can also be regulated by factors unrelated to metabolic control. Several studies suggest a link between stress, access to highly palatable food, and eating disorders. Eating “comfort foods” in response to a negative emotional state, for example, suggests that some individuals overeat to self-medicate. Clinical data suggest that some individuals may develop addiction-like behaviors from consuming palatable foods. Based on this observation, “food addiction” has emerged as an area of intense scientific research. A growing body of evidence suggests that some aspects of food addiction, such as compulsive eating behavior, can be modeled in animals. Moreover, several areas of the brain, including various neurotransmitter systems, are involved in the reinforcement effects of both food and drugs, suggesting that natural and pharmacological stimuli activate similar neural systems. In addition, several recent studies have identified a putative connection between neural circuits activated in the seeking and intake of both palatable food and drugs. The development of well-characterized animal models will increase our understanding of the etiological factors of food addiction and will help identify the neural substrates involved in eating disorders such as compulsive overeating. Such models will facilitate the development and validation of targeted pharmacological therapies. View Full-Text
Keywords: compulsive eating; animal models; striatum; prefrontal cortex; food addiction compulsive eating; animal models; striatum; prefrontal cortex; food addiction
MDPI and ACS Style

Segni, M.D.; Patrono, E.; Patella, L.; Puglisi-Allegra, S.; Ventura, R. Animal Models of Compulsive Eating Behavior. Nutrients 2014, 6, 4591-4609.

AMA Style

Segni MD, Patrono E, Patella L, Puglisi-Allegra S, Ventura R. Animal Models of Compulsive Eating Behavior. Nutrients. 2014; 6(10):4591-4609.

Chicago/Turabian Style

Segni, Matteo D., Enrico Patrono, Loris Patella, Stefano Puglisi-Allegra, and Rossella Ventura. 2014. "Animal Models of Compulsive Eating Behavior" Nutrients 6, no. 10: 4591-4609.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop