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Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials

1,*,† and 2,†
School of Public Health, Medical College of Soochow University, Suzhou 215123, China
Department of Radiotherapy, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2013, 5(9), 3696-3712;
Received: 19 July 2013 / Revised: 9 September 2013 / Accepted: 12 September 2013 / Published: 18 September 2013
(This article belongs to the Special Issue Vitamin A and Carotenoids)
PDF [508 KB, uploaded 18 September 2013]


Epidemiological studies suggested that lycopene supplement could decrease blood pressure, but the results were conflicting. We conducted an updated meta-analysis by screening PubMed databases, and calculated the combined effect size using a random effect model. In addition, subgroup analysis stratified by baseline blood pressure, lycopene dosage, duration, study location and the funding support of the paper was also conducted. Six studies met our inclusion criteria, and the pooled analysis demonstrated a significant reduction of systolic blood pressure (SBP) (mean SBP = −4.953 [−8.820, −1.086], p = 0.012) with obvious heterogeneity (p = 0.034, I2 = 58.5%). Subgroup analysis results showed that higher dosage of lycopene supplement (>12 mg/day) could lower SBP more significantly, especially for participants with baseline SBP >120 mmHg, or Asians, while lycopene intervention had no statistical effect on diastolic blood pressure (DBP) (mean DBP = −3.809 [−8.177, 0.560], p = 0.087), and obvious heterogeneity was also observed (p = 0.074, I2 = 53.1%). Our present study suggests that lycopene supplement >12 mg/day might effectively decrease SBP, particularly among Asians or population with higher baseline SBP. View Full-Text
Keywords: lycopene; blood pressure; intervention trials; meta-analysis lycopene; blood pressure; intervention trials; meta-analysis

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Li, X.; Xu, J. Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials. Nutrients 2013, 5, 3696-3712.

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