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Open AccessArticle

Non-Viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a New Approach to Helicobacter pylori Control in Humans

Experimental and Clinical Research Center, Charité Campus Berlin-Buch (CCB), Lindenberger Weg 80, Berlin 13125, Germany
HealthTwiSt GmbH, Lindenberger Weg 80, Berlin 13125, Germany
Author to whom correspondence should be addressed.
Nutrients 2013, 5(8), 3062-3073;
Received: 15 April 2013 / Revised: 21 June 2013 / Accepted: 22 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Nutrition and Infectious Diseases)
PDF [381 KB, uploaded 2 August 2013]


Prevalence of infections by Helicobacter pylori, a pathogen involved in a number of gastrointestinal diseases, remains high in developing countries. Management of infections by eradication is not always an option. Lactobacillus reuteri (L. reuteri) DSMZ17648 (Pylopass™/Lonza) specifically co-aggregates H. pylori in vitro and was shown to reduce 13C urea breath test in vivo. In this pilot study, we tried to replicate previous findings in an independent sample and to evaluate effects of spray-drying vs. freeze-drying of cultures. A single-blinded, placebo-controlled study was done in 22 H. pylori positive, asymptomatic adults. H. pylori levels were determined by 13C-urea-breath method after 14 days of supplementation, as well as after 6, 12, and 24 weeks follow-up. In the test group, but not in the placebo group, a significant reduction of H. pylori was observed. For the first time, spray-dried cells of L. reuteri DSMZ17648 have been used in a human study and results are in line with the first study results, supplementing with freeze-dried material. This is of special interest as spray-drying results in dead cell material, meaning that the effect of L. reuteri must be independent of its probiotic activity. These results confirm the potential of Pylopass™ as a novel way to reduce the load of H. pylori. View Full-Text
Keywords: Helicobacter pylori; Lactobacillus reuteri; urea breath test Helicobacter pylori; Lactobacillus reuteri; urea breath test

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Mehling, H.; Busjahn, A. Non-Viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a New Approach to Helicobacter pylori Control in Humans. Nutrients 2013, 5, 3062-3073.

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