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Fat Depots, Free Fatty Acids, and Dyslipidemia

1
Division of Primary Care Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
2
Division of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
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Author to whom correspondence should be addressed.
Nutrients 2013, 5(2), 498-508; https://doi.org/10.3390/nu5020498
Received: 31 December 2012 / Revised: 31 January 2013 / Accepted: 4 February 2013 / Published: 7 February 2013
(This article belongs to the Special Issue Dyslipidemia and Obesity)
Body fat deposition and excess free fatty acid (FFA) metabolism contribute to dyslipidemia and the adverse health consequences of obesity. Individuals with upper body obesity have impaired functioning of adipocytes, the primary fatty acid storage site. Excess visceral fat is strongly associated with impaired suppression of FFA release in response to insulin, as well as with hypertriglyceridemia and low concentrations of high density lipoprotein (HDL) cholesterol. High FFA concentrations can induce insulin resistance in muscle and liver. Furthermore, failure of hyperinsulinemia to normally suppress FFA is associated with impaired carbohydrate oxidation and muscle glucose storage, reduced hepatic insulin clearance and elevated triglycerides. Understanding the impact of body fat distribution on FFA metabolism and dyslipidemia is critical for determining the link between overweight and obesity and cardiovascular disease risk. In the current review, we will explore the relationship between adipose tissue, body fat depots, and FFA metabolism. View Full-Text
Keywords: free fatty acid; fat depots; dyslipidemia free fatty acid; fat depots; dyslipidemia
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Ebbert, J.O.; Jensen, M.D. Fat Depots, Free Fatty Acids, and Dyslipidemia. Nutrients 2013, 5, 498-508.

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