Components of an Anticancer Diet: Dietary Recommendations, Restrictions and Supplements of the Bill Henderson Protocol
Abstract
:1. Introduction
2. The Basis for the BHP
Borrowing from the Budwig Diet: An Historical Basis for Lack of Oxygen
3. A Rationale for the Dietary Components: Restoring an Oxygen Rich Environment
3.1. Increasing the Solubility of Fats
3.2. Restrictions of the Budwig Diet
4. Cancer and the Budwig Diet
5. Modifications of the Budwig Diet for Inclusion in the BHP
Lipid Metabolism: A Modern Perspective
6. The Supplemental Components of the Bill Henderson Protocol
6.1. Beta-Glucan: Strengthening the Immune System
6.2. Barley Grass: Countering Acidity
6.3. Nutrient Mixture: The Claim of Preventing Metastases
Component | Source recommended by BHP | Daily dose recommended while on the BHP |
---|---|---|
Cottage cheese | organic, low fat | 2/3 Cup (mixed with flaxseed oil) |
Flaxseed oil | Barleans | 6 Tablespoons (mixed with cottage cheese) |
Beta glucan | Transfer Point | 500 mg/23 kg body weight |
Barley grass | Green Supreme | 20 tablets divided into three doses |
Heart plus | Our Health Coop | 2 capsules/TID, to be taken with green tea extract |
Green tea extract | Our Health Coop | 1 capsule/TID, to be taken with Heart plus |
Daily advantage | Mountain Home Nutritionals | 1 packet/BID (8 capsules/packet) |
6.4. Multivitamin/Mineral Supplement
Nutrient | Total daily amount advised in the BHP [1] (pp. 57–59) | Daily recommended intake (male 51–70 y) [7] | Daily recommended intake (female 51–70 y) [7] | Tolerable upper intake level (adults 19–70 y) [99] |
---|---|---|---|---|
Vitamin A | 3030 µg/10000 IU * | 900 µg or 2970 IU | 700 µg or 2310 IU | 3000 µg/day |
Vitamin C | 4000 mg * | 90 mg | 75 mg | 2000 mg/day |
Vitamin D | 40 µg/1600 IU | 10 µg or 400 IU | 10 µg or 400 IU | 50 µg/day |
Vitamin K | 120 µg ** | 120 µg | 90 µg | ND |
Vitamin E | 800 IU/536 mg | 15 mg | 15 mg | 1000 mg/day |
Thiamin | 100 mg ** | 1.2 mg | 1.1 mg | ND |
Riboflavin | 100 mg ** | 1.3 mg | 1.1 mg | ND |
Niacin | 352 mg * | 16 mg | 14 mg | 35 mg/day |
Vitamin B6 | 220 mg * | 1.7 mg | 1.5 mg | 100 mg/day |
Folic Acid | 800 µg | 400 µg | 400 µg | 1000 µg/day |
Vitamin B12 | 200 µg ** | 2.4 µg | 2.4 µg | ND |
Biotin | 600 µg ** | 30 µg | 30 µg | ND |
Pantothenic acid | 300 mg ** | 5 mg | 5 mg | ND |
Calcium | 2000 mg | 1200 mg | 1200 mg | 2.5 g/day |
Iodine | 200 µg | 150 µg | 150 µg | 1100 µg/day |
Magnesium | 1000 mg * | 420 mg | 320 mg | 350 mg/day |
Zinc | 40 mg | 11 mg | 8 mg | 40 mg |
Selenium | 400 µg | 55 µg | 55 µg | 400 µg/day |
Copper | 4000 µg | 900 µg | 900 µg | 10000 µg/day |
Manganese | 20 mg * | 2.3 mg | 1.8 mg | 11 mg/day |
Chromium | 400 µg ** | 30 µg | 20 µg | ND |
Molybdenum | 200 µg | 45 µg | 45 µg | 2000 µg/day |
Potassium | 200 mg | 4.7g | 4.7g | ND |
Choline | 200 mg | 550 mg | 425 mg | 3.5 g/day |
Vanadium | 0.300 mg | ND | ND | 1.8 mg/day |
Boron | 2 mg | ND | ND | 20 mg |
Quercitin | 100 mg | ND | ND | ND |
N-acetyl cysteine | 100 mg | ND | ND | ND |
Trace mineral complex | 50 mg | ND | ND | ND |
PABA | 60 mg | ND | ND | ND |
Inositol | 200 mg | ND | ND | ND |
Silica | 52 mg | ND | ND | ND |
Rutin | 20 mg | ND | ND | ND |
Hesperidin | 20 mg | ND | ND | ND |
Beta Carotene | 15000 IU | ND | ND | ND |
Tocotrienols | 40 mg | ND | ND | ND |
Coenzyme Q10 | 20 mg | ND | ND | ND |
Alpha lipoic acid | 20 mg | ND | ND | ND |
Lutein | 12 mg | ND | ND | ND |
Lycopene | 6 mg | ND | ND | ND |
EPA (eicosapentaenoic acid) | 200 mg | ND | ND | ND |
DHA (docosahexaenoic acid) | 300 mg | ND | ND | ND |
Omega 3 fatty acids | 100 mg | 1600 mg | 1100 mg | ND |
Gamma linolenic acid | 100 mg | ND | ND | ND |
Ox bile | 100 mg | ND | ND | ND |
Pancreatin | 100 mg | ND | ND | ND |
Lipase | 20 mg | ND | ND | ND |
Cellulase | 20 mg | ND | ND | ND |
Maltase | 20 mg | ND | ND | ND |
Protease | 20 mg | ND | ND | ND |
Amylase | 20 mg | ND | ND | ND |
Daily advantage herbal | Daily dose suggested in the BHP | Natural standard grade | American Pharmaceutical Association’s numerical value |
---|---|---|---|
Spirulina | 1500 mg | C (various) | 4 |
Turmeric | 400 mg | C * | 3 |
L-Taurine | 400 mg | B (nutritional deficiency) | N/A |
Siberian ginseng root and extract | 460 mg | C * | 2 |
Bee pollen | 200 mg | C ** | 3 |
L-Carnitine | 200 mg | A (nutritional deficiency) | 3 |
Royal jelly | 100 mg | N/A | 4 |
Astragalus | 100 mg | C *** | 3 |
Ginger root | 100 mg | C ** | 1 |
Gymnema sylvestre | 100 mg | B (diabetes) | 2 |
Green tea extract | 100 mg | C * | 3 |
Panax ginseng | 80 mg | C | 2 |
Gingko biloba | 20 mg | C *** | 1 |
- A- strong scientific evidence;
- B- good scientific evidence;
- C- unclear or conflicting scientific evidence;
- D- fair scientific evidence;
- F- strong negative evidence.
- Years of use and extensive, high-quality studies indicate that this substance is very effective and safe when used in commonly reported dosages.
- According to a number of well-designed studies and common use, this substance appears to be relatively effective and safe when used in commonly reported dosages.
- Studies on the effectiveness and safety of this substance are conflicting or there are not enough studies to draw a conclusion.
- Research indicates that this substance will not fulfill the claims made for it, but that it is also unlikely to cause any harm.
- Studies indicate that there is a definite hazard in using this substance, even in recommended amounts [103] (pp. 12–13).
7. Dietary Restrictions of the Bill Henderson Protocol: Reducing Toxicity
7.1. Meat
7.2. Dairy
7.3. Gluten
7.4. Sugar and Processed Food
- Obesity causes an elevation of insulin and leptin levels, which can promote the growth of cancer. Elevated leptin levels are associated with colorectal and prostate cancer.
- Insulin resistance is increased, causing the pancreas to compensate by increasing insulin production. Hyperinsulinaemia is correlated with an increased risk of cancers of the colon and endometrium, and possibly of the pancreas and kidney.
- Higher levels of body fat increases the level of estradiol in men and women and may also raise testosterone levels in women. Increased levels of these sex steroid hormones are strongly associated with endometrial cancer and postmenopausal breast cancer and may increase risks for colon and other cancers.
- Adipose tissue promotes inflammatory factors in the body. Obese individuals have higher concentrations of interleukin-6, C-reactive protein and tumour necrosis factor. Leptin, which again is raised in cases of obesity, also functions as an inflammatory cytokine. Chronic inflammation can increase ones risk of cancer [40] (p. 39).
7.5. Alcohol
8. Discussion
9. Conclusion
Acknowledgements
References
- Henderson, B. Cancer-Free: Your Guide to Gentle Non-Toxic Healing, 2nd ed; Booklocker.com: Bangor, ME, USA, 2007. [Google Scholar]
- Evans, M.; Shaw, A.; Thompson, E.A.; Falk, S.; Turton, P.; Thompson, T.; Sharp, D. Decisions to use complementary and alternative medicine (CAM) by male cancer patients: information‑seeking roles and types of evidence used. BMC Complement. Altern. Med. 2007, 7, 25. [Google Scholar]
- Montazeri, A.; Sajadian, A.; Ebrahimi, M.; Haghighat, S.; Harirchi, I. Factors predicting the use of complementary and alternative therapies among cancer patients in Iran. Eur. J. Cancer Care (Engl.) 2007, 16, 144–149. [Google Scholar]
- Henderson, B. Beating Cancer Gently Home Page. 2010. Available online: http://www.beating-cancer-gently.com (accessed on 21 June 2010).
- Kristoffersen, A.E.; Fonnebo, V.; Norheim, A.J. Do cancer patients with a poor prognosis use complementary and alternative medicine more often than others? J. Altern. Complement. Med. 2009, 15, 35–40. [Google Scholar]
- American Cancer Society. Questionable methods of cancer management: “nutritional” therapies. CA Cancer J. Clin. 1993, 43, 309–319.
- Institute of Medicine. Daily Recommended Intakes. 2005. Available online: http://books.nap.edu/openbook.php?record_id=10490&page=1320 (accessed on 22 June 2010).
- Henderson, B. Buy the Book. Beating Cancer Gently Web site. 2010. Available online: http://www.beating-cancer-gently.com/buybook.html (accessed on 21 June 2010).
- Page, S.; Mannion, C.; Bell, L.H.; Verhoef, M.J. The Bill Henderson Protocol: Consumer perspective and practices on an alternative dietary intervention for cancer treatment and cure. Complement. Ther. Med. 2010, unpublished work. [Google Scholar]
- Budwig, J. Remarks on Homann and Otto’s, Treatment of cancer patients with positive-pressure ether. Hippokrates 1953, 24, 600–601. [Google Scholar]
- Budwig, J. Cytostatic or cytodynamic control of cancer? Hippokrates 1956, 27, 605–612. [Google Scholar] [PubMed]
- Budwig, J. Photo-elements of life as an anti-carcinoma factor, successful as a preventive and in the progressive state of the illness. Minerva Ginecol. 1971, 23, 115–117. [Google Scholar]
- Budwig, J. Cancer: The Problem and the Solution; Nexus: Kernen, Germany, 2005. [Google Scholar]
- Hans Krebs. Nobel Prize Web site. 2010. Available online: http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html (accessed on 26 October 2010).
- Otto Warburg. Nobel Prize Web site. 2009. Available online: http://nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html (accessed on 15 September 2009).
- Otto Warburg—Yellow enzyme. Encyclopedia Britannica. 2009. Available online: http://www.britannica.com/EBchecked/topic/635734/Otto-Warburg#ref=ref139725 (accessed on 15 September 2009).
- Warburg, O. The Chemical Constitution of Respiration Ferment. Science 1928, 68, 437–443. [Google Scholar]
- Warburg, O. On respiratory impairment in cancer cells. Science 1956, 124, 269–270. [Google Scholar]
- Warburg, O. On the origin of cancer cells. Science 1956, 123, 309–314. [Google Scholar]
- Budwig, J. Flax Oil as a True Aid against Arthritis, Heart Infarction, Cancer and Other Diseases; Apple Publishing Company: Vancouver, BC, Canada, 1994. [Google Scholar]
- Kaufmann, H.; Budwig, J.; Duddek, E. Die Papier-Chromatographie auf dem Fettgebiet VI: Anwendung auf Seifen. Fette und Seifen 1951, 53, 285–288. [Google Scholar]
- Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet IX: Anwendung auf Lackrohstoffe. Fette und Seifen 1951, 53, 408–412. [Google Scholar]
- Kaufmann, H.; Budwig, J.; Szakall, A. Die Papier-Chromatographie auf dem Fettgebiet VIII: Der Lipoid-Nachschub in der lebenden menschlichen Haut und seine papier-chromatographische Bestimmung. Fette und Seifen 1951, 53, 406–408. [Google Scholar]
- Kaufmann, H.; Budwig, J. Zur Biologie der Fette V: Die Papier-Chromatographie der Blutlipoide, Geschwulstproblem und Fettforschung. Fette und Seifen 1952, 54, 156–165. [Google Scholar]
- Kaufmann, H.; Budwig, J.; Schmidt, C. Die Papier-Chromatographie auf dem Fettgebiet XI: Nachweis und Trennung von Konjuen-Fettsäuren. Fette und Seifen 1952, 54, 10–12. [Google Scholar]
- Kaufmann, H.; Budwig, J.; Schmidt, C. Die Papier-Chromatographie auf dem Fettgebiet XII: Nachweis und Trennung von Konjuen-Fet säuren, 2. Teil. Fette und Seifen 1952, 54, 73–76. [Google Scholar]
- Kaufmann, H.; Budwig, J. Der «Schaumtest» in der Papier-Chromatographie. Fette und Seifen 1950, 52, 555–556. [Google Scholar]
- Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet IV: Die Radiometrie der Ölsäure. Fette und Seifen 1951, 53, 69–73. [Google Scholar]
- Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet VII: Nachweis und Trennung von Fettsäuren. Fette und Seifen 1951, 53, 390–399. [Google Scholar]
- Kaufmann, H.; Budwig, J. Dei Papier-Chromatographie auf dem Fettgebiet V: Die radiometrische Jodzahl der Fette. Fette und Seifen 1951, 53, 253–259. [Google Scholar]
- Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet XIV: Untersuchung von ›Poly-Ölen‹. Fette und Seifen 1952, 54, 348–356. [Google Scholar]
- Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet X: Fluoreszenz-Farben als Indikatoren bei der papyrographischen Analyse von Fettsäuren und Fetten. Fette und Seifen 1952, 54, 7–10. [Google Scholar]
- Gonzalez, C.A.; Riboli, E. Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur. J. Cancer 2010, 46, 2555–2562. [Google Scholar]
- Hooper, L.; Summerbell, C.D.; Higgins, J.P.; Thompson, R.L.; Clements, G.; Capps, N.; Davey, S.; Riemersma, R.A.; Ebrahim, S. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane. Database Syst. Rev. 2001, CD002137. [Google Scholar]
- Flaxseed oil. Natural Standard Web site. 2010. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/aux1-flaxseed.asp&patientVersion=/monographs/herbssupplements/patient-flaxseed.asp (accessed on 21 June 2010).
- Marnett, L.J. Oxyradicals and DNA damage. Carcinogenesis 2000, 21, 361–370. [Google Scholar]
- Valko, M.; Izakovic, M.; Mazur, M.; Rhodes, C.J.; Telser, J. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem. 2004, 266, 37–56. [Google Scholar]
- Peter Mitchell. Nobel Prize Web site. 2010. Available online: http://nobelprize.org/nobel_prizes/chemistry/laureates/1978/ (accessed on 26 October 2010).
- Colombo, M.L. An update on vitamin E, tocopherol and tocotrienol—perspectives. Molecules 2010, 15, 2103–2113. [Google Scholar]
- Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Report of the World Cancer Research Fund and American Institute for Cancer Research. Chapter 2. The Cancer Process. 2007. Available online: http://www.dietandcancerreport.org/downloads/chapters/chapter_02.pdf (accessed on 28 June 2010).
- Mahan, L.K.; Escott-Stump, S. Krause’s Food, Nutrition & Diet Therapy, 11th ed; Saunders: Philadelphia, PA, USA, 2004. [Google Scholar]
- Roberts, D.C. Quick weight loss: Sorting fad from fact. Med. J. Aust. 2001, 175, 637–640. [Google Scholar]
- Groff, J.; Gropper, S. Advanced Nutrition and Human Metabolism, 3rd ed; Wadsworth: Belmont, CA, USA, 2000; pp. 133–135. [Google Scholar]
- Brody, T. Nutritional Biochemistry, 2nd ed; Academic Press: San Diego, CA, USA, 1999. [Google Scholar]
- Olson, R.E. Discovery of the lipoproteins, their role in fat transport and their significance as risk factors. J. Nutr. 1998, 128, 439S–443S. [Google Scholar]
- Goldstein, J.L.; Brown, M.S. The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 2009, 29, 431–438. [Google Scholar]
- Chajes, V.; Thiebaut, A.C.M.; Rotival, M.; Gauthier, E.; Maillard, V.; Boutron-Ruault, M.C.; Joulin, V.; Lenoir, G.M.; Clavel-Chapelon, F. Association between Serum trans-Monounsaturated Fatty Acids and Breast Cancer Risk in the E3N-EPIC Study. Am. J. Epidemiol. 2008, 167, 1312–1320. [Google Scholar]
- Lopez-Garcia, E.; Schulze, M.B.; Meigs, J.B.; Manson, J.E.; Rifai, N.; Stampfer, M.J.; Willett, W.C.; Hu, F.B. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J. Nutr. 2005, 135, 562–566. [Google Scholar]
- Remig, V.; Franklin, B.; Margolis, S.; Kostas, G.; Nece, T.; Street, J.C. Trans fats in America: A review of their use, consumption, health implications, and regulation. J. Am. Diet. Assoc. 2010, 110, 585–592. [Google Scholar]
- Ratnayake, W.M.; L’Abbe, M.R.; Farnworth, S.; Dumais, L.; Gagnon, C.; Lampi, B.; Casey, V.; Mohottalage, D.; Rondeau, I.; Underhill, L.; et al. Trans fatty acids: Current contents in Canadian foods and estimated intake levels for the Canadian population. J. AOAC Int. 2009, 92, 1258–1276. [Google Scholar] [PubMed]
- Michels, K.B.; Willett, W.C. The Women’s Health Initiative Randomized Controlled Dietary Modification Trial: A post-mortem. Breast Cancer Res. Treat. 2009, 114, 1–6. [Google Scholar]
- Mason, J.K.; Chen, J.; Thompson, L.U. Flaxseed oil-trastuzumab interaction in breast cancer. Food Chem. Toxicol. 2010, 48, 2223–2226. [Google Scholar]
- Saggar, J.K.; Chen, J.; Corey, P.; Thompson, L.U. Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor‑signaling pathways. Mol. Nutr. Food Res. 2010, 54, 415–425. [Google Scholar]
- Natural Standard Beta-glucan. Natural Standard Web site. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/betaglucan.asp&patientVersion=/monographs/herbssupplements/patient-betaglucan.asp (accessed on 12 October 2010).
- Akramiene, D.; Kondrotas, A.; Didziapetriene, J.; Kevelaitis, E. Effects of beta-glucans on the immune system. Medicina (Kaunas) 2007, 43, 597–606. [Google Scholar] [PubMed]
- Baran, J.; Allendorf, D.J.; Hong, F.; Ross, G.D. Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice. Folia Histochem. Cytobiol. 2007, 45, 107–114. [Google Scholar]
- Chan, G.C.; Chan, W.K.; Sze, D.M. The effects of beta-glucan on human immune and cancer cells. J. Hematol. Oncol. 2009, 2, 25. [Google Scholar]
- Chen, J.; Seviour, R. Medicinal importance of fungal beta-(1→3), (1→6)-glucans. Mycol. Res. 2007, 111, 635–652. [Google Scholar]
- Fujimoto, K.; Tomonaga, M.; Goto, S. A case of recurrent ovarian cancer successfully treated with adoptive immunotherapy and lentinan. Anticancer Res. 2006, 26, 4015–4018. [Google Scholar]
- Demir, G.; Klein, H.O.; Mandel-Molinas, N.; Tuzuner, N. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int. Immunopharmacol. 2007, 7, 113–116. [Google Scholar]
- Ferrone, M.; Raimondo, M.; Scolapio, J.S. Pancreatic enzyme pharmacotherapy. Pharmacotherapy 2007, 27, 910–920. [Google Scholar]
- Arnett, T.R. Extracellular pH regulates bone cell function. J. Nutr. 2008, 138, 415S–418S. [Google Scholar]
- Fenton, T.R.; Eliasziw, M.; Lyon, A.W.; Tough, S.C.; Hanley, D.A. Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. Am. J. Clin. Nutr. 2008, 88, 1159–1166. [Google Scholar]
- Fenton, T.R.; Eliasziw, M.; Tough, S.C.; Lyon, A.W.; Brown, J.P.; Hanley, D.A. Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study. BMC Musculoskelet. Disord. 2010, 11, 88. [Google Scholar]
- Konig, D.; Muser, K.; Dickhuth, H.H.; Berg, A.; Deibert, P. Effect of a supplement rich in alkaline minerals on acid-base balance in humans. Nutr. J. 2009, 8, 23. [Google Scholar]
- Bar-Sela, G.; Tsalic, M.; Fried, G.; Goldberg, H. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: A pilot study. Nutr. Cancer 2007, 58, 43–48. [Google Scholar]
- Rath, M.; Pauling, L. Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs. J. Orthomol. Med. 1992, 7, 17–23. [Google Scholar]
- Rath, M. Reducing the Risk for Cardiovascular Disease with Nutritional Supplements. J. Orthomol. Med. 1992, 7, 153–162. [Google Scholar]
- Rath Institute Research. Dr. Mathias Rath Institute Web site. 2009. Available online: http://www4.dr-rath-foundation.org/pdf-files/cancerresearch.pdf (accessed on 23 June 2010).
- Demeule, M.; Brossard, M.; Page, M.; Gingras, D.; Beliveau, R. Matrix metalloproteinase inhibition by green tea catechins. Biochim. Biophys. Acta 2000, 1478, 51–60. [Google Scholar]
- Ivanov, V.; Ivanova, S.; Roomi, M.W.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Naturally produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells. Med. Oncol. 2007, 24, 209–217. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anti-tumor effect of ascorbic acid, lysine, proline, arginine, and epigallocatechin gallate on prostate cancer cell lines PC-3, LNCaP, and DU145. Res. Commun. Mol. Pathol. Pharmacol. 2004, 115–116, 251–264. [Google Scholar] [PubMed]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anti-angiogenic effects of a nutrient mixture on human umbilical vein endothelial cells. Oncol. Rep. 2005, 14, 1399–1404. [Google Scholar]
- Roomi, M.W.; Roomi, N.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol. Rep. 2005, 14, 807–815. [Google Scholar]
- Roomi, M.W.; Roomi, N.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague-Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract. Breast Cancer Res. 2005, 7, R291–R295. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vitro and in vivo antitumorigenic activity of a mixture of lysine, proline, ascorbic acid, and green tea extract on human breast cancer lines MDA-MB-231 and MCF-7. Med. Oncol. 2005, 22, 129–138. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of a combination of lysine, proline, arginine, ascorbic acid, and green tea extract on pancreatic cancer cell line MIA PaCa-2. Int. J. Gastrointest. Cancer 2005, 35, 97–102. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer PC-3 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry. In Vivo 2005, 19, 179–183. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: Evaluation of tumor growth and immunohistochemistry. Oncol. Rep. 2005, 13, 421–425. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing’s sarcoma SK–ES.1. Oncol. Rep. 2005, 13, 253–257. [Google Scholar] [PubMed]
- Roomi, M.W.; Roomi, N.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of pulmonary metastasis of melanoma b16fo cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic Acid, lysine, proline, arginine, and green tea extract. Exp. Lung Res. 2006, 32, 517–530. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry. Med. Oncol. 2006, 23, 411–418. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anticancer effect of lysine, proline, arginine, ascorbic acid and green tea extract on human renal adenocarcinoma line 786-0. Oncol. Rep. 2006, 16, 943–947. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Suppression of human cervical cancer cell lines Hela and DoTc2 4510 by a mixture of lysine, proline, ascorbic acid, and green tea extract. Int. J. Gynecol. Cancer 2006, 16, 1241–1247. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of malignant mesothelioma cell matrix metalloproteinase production and invasion by a novel nutrient mixture. Exp. Lung Res. 2006, 32, 69–79. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24. Int. J. Urol. 2006, 13, 415–419. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on human fibrosarcoma cells HT-1080. Med. Oncol. 2006, 23, 105–111. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract. J. Obstet. Gynaecol. Res. 2006, 32, 148–154. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Netke, S.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058. In Vivo 2006, 20, 25–32. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of cell invasion and MMP production by a nutrient mixture in malignant liposarcoma cell line SW-872. Med. Oncol. 2007, 24, 394–401. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture. Med. Oncol. 2007, 24, 231–238. [Google Scholar]
- Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibitory effects of a nutrient mixture on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity. Med. Oncol. 2007, 24, 183–188. [Google Scholar]
- Roomi, M.W.; Roomi, N.W.; Kalinovsky, T.; Ivanov, V.; Rath, M.; Niedzwiecki, A. Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture. Med. Oncol. 2008, 25, 333–340. [Google Scholar]
- Roomi, M.W.; Bhanap, B.A.; Roomi, N.W.; Rath, M.; Niedzwiecki, A. Antineoplastic effects of nutrient mixture on raji and jurkat t cells: the two highly aggressive non hodgkin’s lymphoma cell lines. Exp. Oncol. 2009, 31, 149–155. [Google Scholar]
- Roomi, M.W.; Roomi, N.W.; Kalinovsky, T.; Rath, M.; Niedzwiecki, A. Marked inhibition of growth and invasive parameters of head and neck squamous carcinoma FaDu by a nutrient mixture. Integr. Cancer Ther. 2009, 8, 168–176. [Google Scholar]
- Waheed, R.M.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549. Exp. Lung Res. 2006, 32, 441–453. [Google Scholar]
- Rundhaug, J.E. Matrix Metalloproteinases, Angiogenesis, and Cancer: Commentary re: A. C. Lockhart et al., Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor. Clin. Cancer Res., 9: 00-00, 2003. Clin. Cancer Res. 2003, 9, 551–554. [Google Scholar] [PubMed]
- Lode, H.N.; Huebener, N.; Strandsby, A.; Gaedicke, G. Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model. Pediatr. Blood Cancer 2008, 50, 284–288. [Google Scholar]
- Tolerable Upper Intake Levels. Institute of Medicine. 2005. Available online: http://books.nap.edu/openbook.php?record_id=10490&page=1326 (accessed on 22 June 2010).
- Natural Standard Home. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/index.asp (accessed on 9 October 2009).
- Natural Standard Online Database. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/index.asp?file=/html/about.html (accessed on 9 October 2009).
- Natural Standard grading scale. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/monographs/flashcards/flashcard-spirulina.asp (accessed on 9 October 2009).
- Peirce, A. The American Pharmaceutical Association Practical Guide to Natural Medicines; Stonesong Press Book: New York, NY, USA, 1999. [Google Scholar]
- Lee, J.E.; Mannisto, S.; Spiegelman, D.; Hunter, D.J.; Bernstein, L.; van den Brandt, P.A.; Buring, J.E.; Cho, E.; English, D.R.; Flood, A.; et al. Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: A pooled analysis of 13 prospective studies. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 1730–1739. [Google Scholar]
- Lin, J.; Kamat, A.; Gu, J.; Chen, M.; Dinney, C.P.; Forman, M.R.; Wu, X. Dietary intake of vegetables and fruits and the modification effects of GSTM1 and NAT2 genotypes on bladder cancer risk. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 2090–2097. [Google Scholar]
- Satia, J.A.; Tseng, M.; Galanko, J.A.; Martin, C.; Sandler, R.S. Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer Study. Nutr. Cancer 2009, 61, 179–193. [Google Scholar]
- Van, H.L. Nutritional research: The power behind the fad-free diet. J. Am. Diet. Assoc. 2007, 107, 371. [Google Scholar]
- De, S.E.; Boffetta, P.; Deneo-Pellegrini, H.; Ronco, A.L.; Aune, D.; Acosta, G.; Brennan, P.; Mendilaharsu, M.; Ferro, G. Meat intake, meat mutagens and risk of lung cancer in Uruguayan men. Cancer Causes Control 2009, 20, 1635–1643. [Google Scholar]
- Ferrucci, L.M.; Cross, A.J.; Graubard, B.I.; Brinton, L.A.; McCarty, C.A.; Ziegler, R.G.; Ma, X.; Mayne, S.T.; Sinha, R. Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br. J. Cancer 2009, 101, 178–184. [Google Scholar]
- Taylor, V.H.; Misra, M.; Mukherjee, S.D. Is red meat intake a risk factor for breast cancer among premenopausal women? Breast Cancer Res Treat. 2009, 117, 1–8. [Google Scholar] [CrossRef]
- Pala, V.; Krogh, V.; Berrino, F.; Sieri, S.; Grioni, S.; Tjonneland, A.; Olsen, A.; Jakobsen, M.U.; Overvad, K.; Clavel-Chapelon, F.; et al. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am. J. Clin. Nutr. 2009, 90, 602–612. [Google Scholar]
- Ferrucci, L.M.; Sinha, R.; Graubard, B.I.; Mayne, S.T.; Ma, X.; Schatzkin, A.; Schoenfeld, P.S.; Cash, B.D.; Flood, A.; Cross, A.J. Dietary meat intake in relation to colorectal adenoma in asymptomatic women. Am. J. Gastroenterol. 2009, 104, 1231–1240. [Google Scholar]
- Pauwels, E.K.; Kairemo, K. Fatty acid facts, part II: role in the prevention of carcinogenesis, or, more fish on the dish? Drug News Perspect. 2008, 21, 504–510. [Google Scholar]
- Chavarro, J.E.; Stampfer, M.J.; Hall, M.N.; Sesso, H.D.; Ma, J. A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. Am. J. Clin. Nutr. 2008, 88, 1297–1303. [Google Scholar]
- Melnik, B.C. Milk—the promoter of chronic Western diseases. Med. Hypotheses 2009, 72, 631–639. [Google Scholar]
- Van der Pols, J.C.; Bain, C.; Gunnell, D.; Smith, G.D.; Frobisher, C.; Martin, R.M. Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort. Am. J. Clin. Nutr. 2007, 86, 1722–1729. [Google Scholar]
- Huncharek, M.; Muscat, J.; Kupelnick, B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr. Cancer 2009, 61, 47–69. [Google Scholar]
- Lee, S.A.; Shu, X.O.; Yang, G.; Li, H.; Gao, Y.T.; Zheng, W. Animal origin foods and colorectal cancer risk: A report from the Shanghai Women’s Health Study. Nutr. Cancer 2009, 61, 194–205. [Google Scholar]
- Lappe, J.M.; Travers-Gustafson, D.; Davies, K.M.; Recker, R.R.; Heaney, R.P. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am. J. Clin. Nutr. 2007, 85, 1586–1591. [Google Scholar]
- Pilz, S.; Tomaschitz, A.; Obermayer-Pietsch, B.; Dobnig, H.; Pieber, T.R. Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer Res. 2009, 29, 3699–3704. [Google Scholar]
- Battais, F.; Richard, C.; Jacquenet, S.; Denery-Papini, S.; Moneret-Vautrin, D.A. Wheat grain allergies: An update on wheat allergens. Eur. Ann. Allergy Clin. Immunol. 2008, 40, 67–76. [Google Scholar]
- Freeman, H.J. Celiac disease (gluten-sensitive enteropathy). Minerva Gastroenterol. Dietol. 2010, 56, 245–249. [Google Scholar]
- Freeman, H.J. Adult celiac disease and its malignant complications. Gut Liver 2009, 3, 237–246. [Google Scholar]
- Jiao, L.; Flood, A.; Subar, A.F.; Hollenbeck, A.R.; Schatzkin, A.; Stolzenberg-Solomon, R. Glycemic index, carbohydrates, glycemic load, and the risk of pancreatic cancer in a prospective cohort study. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 1144–1151. [Google Scholar]
- Polesel, J.; Talamini, R.; Negri, E.; Bosetti, C.; Boz, G.; Lucenteforte, E.; Franceschi, S.; Serraino, D.; La, V.C. Dietary habits and risk of pancreatic cancer: an Italian case-control study. Cancer Causes Control 2010, 21, 493–500. [Google Scholar]
- Mulholland, H.G.; Cantwell, M.M.; Anderson, L.A.; Johnston, B.T.; Watson, R.G.; Murphy, S.J.; Ferguson, H.R.; McGuigan, J.; Reynolds, J.V.; Comber, H.; Murray, L.J. Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Causes Control 2009, 20, 279–288. [Google Scholar]
- Lajous, M.; Boutron-Ruault, M.C.; Fabre, A.; Clavel-Chapelon, F.; Romieu, I. Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am. J. Clin. Nutr. 2008, 87, 1384–1391. [Google Scholar]
- Sieri, S.; Pala, V.; Brighenti, F.; Pellegrini, N.; Muti, P.; Micheli, A.; Evangelista, A.; Grioni, S.; Contiero, P.; Berrino, F.; Krogh, V. Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study. Am. J. Clin. Nutr. 2007, 86, 1160–1166. [Google Scholar]
- Wen, W.; Shu, X.O.; Li, H.; Yang, G.; Ji, B.T.; Cai, H.; Gao, Y.T.; Zheng, W. Dietary carbohydrates, fiber, and breast cancer risk in Chinese women. Am. J. Clin. Nutr. 2009, 89, 283–289. [Google Scholar]
- Polednak, A.P. Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers. Cancer Detect. Prev. 2008, 32, 190–199. [Google Scholar]
- Sears, W. Sugar and immunity. 2009. Available online: http://www.askdrsears.com/html/4/T045000.asp (accessed on 25 June 2010).
- Johansen, D.; Borgstrom, A.; Lindkvist, B.; Manjer, J. Different Markers of Alcohol Consumption, Smoking and Body Mass Index in Relation to Risk of Pancreatic Cancer. A Prospective Cohort Study within the Malmo Preventive Project. Pancreatology 2009, 9, 677–686. [Google Scholar]
- Platek, M.E.; Shields, P.G.; Marian, C.; McCann, S.E.; Bonner, M.R.; Nie, J.; Ambrosone, C.B.; Millen, A.E.; Ochs-Balcom, H.M.; Quick, S.K.; Trevisan, M.; Russell, M.; Nochajski, T.H.; Edge, S.B.; Freudenheim, J.L. Alcohol consumption and genetic variation in methylenetetrahydrofolatereductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 2453–2459. [Google Scholar]
- Poynter, J.N.; Haile, R.W.; Siegmund, K.D.; Campbell, P.T.; Figueiredo, J.C.; Limburg, P.; Young, J.; Le, M.L.; Potter, J.D.; Cotterchio, M.; et al. Associations between Smoking, Alcohol Consumption, and Colorectal Cancer, Overall and by Tumor Microsatellite Instability Status. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 2745–2750. [Google Scholar]
- Gong, Z.; Kristal, A.R.; Schenk, J.M.; Tangen, C.M.; Goodman, P.J.; Thompson, I.M. Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer 2009, 115, 3661–3669. [Google Scholar]
- Parsons, J.K.; Im, R. Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J. Urol. 2009, 182, 1463–1468. [Google Scholar]
- Benedetti, A.; Parent, M.E.; Siemiatycki, J. Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: Results from a case-control study in Montreal. Cancer Detect. Prev. 2009, 32, 352–362. [Google Scholar]
- Flom, J.D.; Ferris, J.S.; Tehranifar, P.; Terry, M.B. Alcohol intake over the life course and mammographic density. Breast Cancer Res Treat. 2009, 117, 643–651. [Google Scholar]
- Guerrero, R.F.; Garcia-Parrilla, M.C.; Puertas, B.; Cantos-Villar, E. Wine, resveratrol and health: A review. Nat. Prod. Commun. 2009, 4, 635–658. [Google Scholar]
- Wallenborg, K.; Vlachos, P.; Eriksson, S.; Huijbregts, L.; Arner, E.S.; Joseph, B.; Hermanson, O. Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Exp. Cell Res. 2009, 315, 1360–1371. [Google Scholar]
- Henderson, B. Testimonials. Beating Cancer Gently Web site. 2010. Available online: http://www.beating-cancer-gently.com/testimonials.html (accessed on 21 June 2010).
- Page, S.; Mannion, C.; Heilman Bell, L.; Verhoef, M. CAM information online: An audit of Internet information on the “Bill Henderson Protocol”. Complement. Ther. Med. 2010, 18, 206–214. [Google Scholar]
- Angelo, L.S.; Kurzrock, R. Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia. Clin. Cancer Res. 2009, 15, 1123–1125. [Google Scholar]
- Lu, Q.Y.; Yang, Y.; Jin, Y.S.; Zhang, Z.F.; Heber, D.; Li, F.P.; Dubinett, S.M.; Sondej, M.A.; Loo, J.A.; Rao, J.Y. Effects of green tea extract on lung cancer A549 cells: Proteomic identification of proteins associated with cell migration. Proteomics 2009, 9, 757–767. [Google Scholar]
- Ohno, S.; Ohno, Y.; Suzuki, N.; Soma, G.; Inoue, M. High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. Anticancer Res. 2009, 29, 809–815. [Google Scholar]
- Philips, B.J.; Coyle, C.H.; Morrisroe, S.N.; Chancellor, M.B.; Yoshimura, N. Induction of apoptosis in human bladder cancer cells by green tea catechins. Biomed. Res. 2009, 30, 207–215. [Google Scholar]
- Yeom, C.H.; Lee, G.; Park, J.H.; Yu, J.; Park, S.; Yi, S.Y.; Lee, H.R.; Hong, Y.S.; Yang, J.; Lee, S. High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. J. Transl. Med. 2009, 7, 70. [Google Scholar]
- Mousa, S.A. Antithrombotic effects of naturally derived products on coagulation and platelet function. Methods Mol. Biol. 2010, 663, 229–240. [Google Scholar]
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Mannion, C.; Page, S.; Bell, L.H.; Verhoef, M. Components of an Anticancer Diet: Dietary Recommendations, Restrictions and Supplements of the Bill Henderson Protocol. Nutrients 2011, 3, 1-26. https://doi.org/10.3390/nu3010001
Mannion C, Page S, Bell LH, Verhoef M. Components of an Anticancer Diet: Dietary Recommendations, Restrictions and Supplements of the Bill Henderson Protocol. Nutrients. 2011; 3(1):1-26. https://doi.org/10.3390/nu3010001
Chicago/Turabian StyleMannion, Cynthia, Stacey Page, Laurie Heilman Bell, and Marja Verhoef. 2011. "Components of an Anticancer Diet: Dietary Recommendations, Restrictions and Supplements of the Bill Henderson Protocol" Nutrients 3, no. 1: 1-26. https://doi.org/10.3390/nu3010001