Dietary Phospholipids and Intestinal Cholesterol Absorption
Jeffrey S. Cohn Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St. Newtown 2042 NSW, Sydney, Australia
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Nutrients 2010, 2(2), 116-127; https://doi.org/10.3390/nu2020116
Received: 27 November 2009 / Accepted: 29 January 2010 / Published: 8 February 2010
(This article belongs to the Special Issue Phospholipid Nutrition)
Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption. Limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man. A number of biological mechanisms have been proposed in order to explain how PL in the gut lumen is able to affect cholesterol uptake by the gut mucosa. Further research is however required to establish whether the ability of PLs to inhibit cholesterol absorption is of therapeutic benefit.
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Keywords:
cardiovascular disease; cholesterol; intestine; micelle; phosphatidylcholine; phosphatidylethanolamine; phospholipid; sphingomyelin
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MDPI and ACS Style
Cohn, J.S.; Kamili, A.; Wat, E.; Chung, R.W.S.; Tandy, S. Dietary Phospholipids and Intestinal Cholesterol Absorption. Nutrients 2010, 2, 116-127.
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