Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study
Abstract
:1. Introduction
2. Material and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 189) | |
---|---|
Age (years) * | 13.12 (6.23) |
Male-to-female | 76/113 |
Weight (kg) * | 48.50 (24.00) |
Height (cm) * | 155.00 (28.00) |
BMI (kg/m2) * | 19.58 (5.26) |
Polyarticular JIA (n; %) | 83 (43.90%) |
Oligoarticular JIA (n; %) | 93 (49.20%) |
Systemic-onset JIA (n; %) | 13 (6.90%) |
Treated with GCs (n; %) | 73 (38.60%) |
Treated with MTX (n; %) | 84 (44.40%) |
Low 25(OH)D Level <20 ng/mL | Normal 25(OH)D Level ≥20 ng/mL | p Value | |
---|---|---|---|
Patients (N; %) | 127 (67.2%) | 62 (32.8%) | |
Age (years) ** | 13.34; (5.18) | 11.84 (8.32) | 0.19 |
Weight (kg) ** | 50.00 (22.00) | 45.35 (33.00) | 0.14 |
Height (kg) ** | 156.50 (25.00) | 148.00 (37.50) | 0.15 |
BMI (kg/m2) ** | 19.81 (4.88) | 19.06 (6.10) | 0.17 |
GCs (mg) ** daily dose | 5.00 (5.00) | 5.00 (5.00) | 0.29 |
MTX (mg) ** weekly dose per m2 | 15.00 (7.50) | 12.5 (7.50) | 0.02 |
CRP (mg/L) ** | 1.00 (3.70) | 1.60 (12.0) | 0.23 |
25(OH)D (ng/mL) ** | 12.00 (8.00) | 25.5 (6.0) | <0.001 |
Ca (mmol/L) * | 2.48 ± 0.09 | 2.52 ± 0.12 | 0.01 |
P (mg/dL) * | 4.50 ± 0.63 | 4.54 ± 0.72 | 0.76 |
ALP (U/L) ** | 165.00 (138.00) | 172.00 (124.00) | 0.70 |
ESR (mm/h) ** | 11.50 (22.00) | 19.00 (30.00) | 0.05 |
JADAS27 score ** | 1.50 (0.70) | 1.50 (0.50) | 0.64 |
MTX weekly dose per m2 | GCs daily dose | |
---|---|---|
25(OH)D | r = −0.33; p = 0.003 | r = −0.08; p = 0.26 |
Calcium | r = −0.31; p = 0.01 | r = −0.23; p = 0.01 |
Phosphate | r = −0.42; p = 0.03 | r = −0.27; p = 0.004 |
ALP | r = −0.14; p = 0.17 | r = −0.79; p = 0.004 |
Coefficient | Standard Error | 95% CI | p Value | ||
---|---|---|---|---|---|
Body weight | 0.09 | 0.40 | −0.69 | 0.87 | 0.82 |
BMI | −0.08 | 0.32 | −0.70 | 0.54 | 0.80 |
GCs daily dose | 0.18 | 0.21 | −0.24 | 0.60 | 0.41 |
MTX weekly dose per m2 | 1.79 | 0.74 | 0.33 | 3.24 | 0.02 |
CRP (mg/L) | −0.29 | 0.23 | −0.74 | 0.17 | 0.21 |
ESR (mm/h) | −0.72 | 0.23 | −0.51 | 0.37 | 0.75 |
Ca (mmol/L) | −0.13 | 0.19 | −0.51 | 0.24 | 0.48 |
P (mg/dL) | 0.32 | 0.21 | −0.10 | 0.73 | 0.13 |
ALP (U/L) | 0.01 | 0.20 | −0.37 | 0.40 | 0.94 |
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Stawicki, M.K.; Abramowicz, P.; Góralczyk, A.; Młyńczyk, J.; Kondratiuk, A.; Konstantynowicz, J. Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study. Nutrients 2022, 14, 1645. https://doi.org/10.3390/nu14081645
Stawicki MK, Abramowicz P, Góralczyk A, Młyńczyk J, Kondratiuk A, Konstantynowicz J. Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study. Nutrients. 2022; 14(8):1645. https://doi.org/10.3390/nu14081645
Chicago/Turabian StyleStawicki, Maciej K., Paweł Abramowicz, Adrian Góralczyk, Justyna Młyńczyk, Anna Kondratiuk, and Jerzy Konstantynowicz. 2022. "Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study" Nutrients 14, no. 8: 1645. https://doi.org/10.3390/nu14081645
APA StyleStawicki, M. K., Abramowicz, P., Góralczyk, A., Młyńczyk, J., Kondratiuk, A., & Konstantynowicz, J. (2022). Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study. Nutrients, 14(8), 1645. https://doi.org/10.3390/nu14081645