The Lactobacillus gasseri G098 Strain Mitigates Symptoms of DSS-Induced Inflammatory Bowel Disease in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Experimental Strain
2.2. Experimental Design
2.3. Histological Analysis
2.4. Quantification of Inflammatory Cytokines in the Serum
2.5. Fecal DNA Extraction, Sequencing, and Analysis
2.6. Statistical Analysis
3. Results
3.1. Lactobacillus Gasseri G098 Alleviated Inflammatory Manifestations in Mice with Colitis
3.2. Lactobacillus Gasseri G098 Intake Reversed DSS-Induced Changes in Serum Pro-/Anti-Inflammatory Cytokine Levels
3.3. Effect of Lactobacillus Gasseri G098 on the Gut Microbiota Composition
3.4. Effect of Lactobacillus Gasseri G098 on the Gut Microbiota Metabolic Pathways
3.5. Correlation between Significant Differential Gut Microbiota with Gut Metabolic Pathways, Serum Cytokines, and DAI
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Zhang, W.-Q.; Quan, K.-Y.; Feng, C.-J.; Zhang, T.; He, Q.-W.; Kwok, L.-Y.; Chen, Y.-F. The Lactobacillus gasseri G098 Strain Mitigates Symptoms of DSS-Induced Inflammatory Bowel Disease in Mice. Nutrients 2022, 14, 3745. https://doi.org/10.3390/nu14183745
Zhang W-Q, Quan K-Y, Feng C-J, Zhang T, He Q-W, Kwok L-Y, Chen Y-F. The Lactobacillus gasseri G098 Strain Mitigates Symptoms of DSS-Induced Inflammatory Bowel Disease in Mice. Nutrients. 2022; 14(18):3745. https://doi.org/10.3390/nu14183745
Chicago/Turabian StyleZhang, Wei-Qin, Ke-Yu Quan, Cui-Jiao Feng, Tao Zhang, Qiu-Wen He, Lai-Yu Kwok, and Yong-Fu Chen. 2022. "The Lactobacillus gasseri G098 Strain Mitigates Symptoms of DSS-Induced Inflammatory Bowel Disease in Mice" Nutrients 14, no. 18: 3745. https://doi.org/10.3390/nu14183745