Next Article in Journal
Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways
Previous Article in Journal
Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study
Article

A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort

by 1 and 2,*
1
Pro Case Management Trials, Denver, CO 80218, USA
2
Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA
*
Author to whom correspondence should be addressed.
Academic Editors: David C. Nieman and Giuseppe Maurizio Campo
Nutrients 2021, 13(7), 2454; https://doi.org/10.3390/nu13072454
Received: 27 May 2021 / Revised: 30 June 2021 / Accepted: 15 July 2021 / Published: 18 July 2021
(This article belongs to the Section Proteins and Amino Acids)
Joint pain and disease affects more than one in four adults in the United States. We conducted a double-blind, randomized, placebo-controlled trial to investigate the efficacy of a hydrolyzed chicken collagen type II (HCII) supplement in reducing joint-related discomfort such as pain and stiffness, and in improving mobility. We enrolled adults aged 40–65 (65.5% were women) who had joint discomfort, but had no co-morbidities, and who were not taking pain medications. The participants were randomized to receive either the HCII supplement (n = 47) or a placebo (n = 43) for eight weeks. At the baseline, and at week 4 and week 8, we administered the Western Ontario and McMaster Universities Arthritis Index (WOMAC) survey with three additional wrist-related questions and the Visual Analog Scale for assessments of joint-related symptoms. In the WOMAC stiffness and physical activity domains and in the overall WOMAC score, the HCII group had a significant reduction in joint-related discomforts compared with the placebo group. For example, at week 4, the HCII group had a 36.9% reduction in the overall WOMAC score, compared with a 14.3% reduction in the placebo group (p = 0.027). This HCII product is effective in reducing joint pain and stiffness and in improving joint function among otherwise healthy adults. View Full-Text
Keywords: collagen type II; joint discomfort; nutritional supplement collagen type II; joint discomfort; nutritional supplement
Show Figures

Figure 1

MDPI and ACS Style

Mohammed, A.; He, S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients 2021, 13, 2454. https://doi.org/10.3390/nu13072454

AMA Style

Mohammed A, He S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. 2021; 13(7):2454. https://doi.org/10.3390/nu13072454

Chicago/Turabian Style

Mohammed, Anaam, and Siran He. 2021. "A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort" Nutrients 13, no. 7: 2454. https://doi.org/10.3390/nu13072454

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop