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Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Katarzyna Śliżewska
Nutrients 2021, 13(7), 2439; https://doi.org/10.3390/nu13072439
Received: 14 May 2021 / Revised: 24 June 2021 / Accepted: 10 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue The Impact of Fermented Food Consumption on Acute or Chronic Diseases)
Patients suffering from critical illness have host inflammatory responses against injuries, such as infection and trauma, that can lead to tissue damage, organ failure, and death. Modulation of host immune response as well as infection and damage control are detrimental factors in the management of systemic inflammation. The gut is the motor of multiple organ failure following injury, and it is recognized that gut dysfunction is one of the causative factors of disease progression. The gut microbiota has a role in maintaining host immunity, and disruption of the gut microbiota might induce an immunosuppressive condition in critically ill patients. Treatment with probiotics and synbiotics has been reported to attenuate systemic inflammation by maintaining gut microbiota and to reduce postoperative infectious complications and ventilator-associated pneumonia. The administration of prophylactic probiotics/synbiotics could be an important treatment option for preventing infectious complications and modulating immunity. Further basic and clinical research is needed to promote intestinal therapies for critically ill patients. View Full-Text
Keywords: microbiota; gut; ICU; immune; ventilator; inflammation; probiotics; prebiotics; synbiotics; critically microbiota; gut; ICU; immune; ventilator; inflammation; probiotics; prebiotics; synbiotics; critically
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MDPI and ACS Style

Shimizu, K.; Ojima, M.; Ogura, H. Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients. Nutrients 2021, 13, 2439. https://doi.org/10.3390/nu13072439

AMA Style

Shimizu K, Ojima M, Ogura H. Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients. Nutrients. 2021; 13(7):2439. https://doi.org/10.3390/nu13072439

Chicago/Turabian Style

Shimizu, Kentaro, Masahiro Ojima, and Hiroshi Ogura. 2021. "Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients" Nutrients 13, no. 7: 2439. https://doi.org/10.3390/nu13072439

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