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Article

β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis

1
School of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan
2
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402367, Taiwan
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Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
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Graduate Program in Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
5
Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402367, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Annunziata Carluccio
Nutrients 2021, 13(7), 2280; https://doi.org/10.3390/nu13072280
Received: 27 April 2021 / Revised: 23 June 2021 / Accepted: 28 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Carotene and Carotenoids and Human Health)
This study was conducted to investigate the β-carotene status in osteoarthritis (OA) patients and examine its relationships with the risk of inflammation and metabolic syndrome. OA patients were stratified by obesity based on body fat percentage (obese OA, n = 44; non-obese OA, n = 56), and sixty-nine subjects without OA or obesity were assigned as a non-obese control group. β-carotene, metabolic parameters, and inflammation status were assessed. Obese OA patients exhibited a significantly higher rate of metabolic syndrome (p = 0.02), abdominal obesity (p < 0.01), and lower β-carotene status (p < 0.01) compared with non-obese OA and non-obese controls. After adjusting for potential confounders, β-carotene status (≥0.8 µM) was significantly inversely correlated with the risk of metabolic syndrome (odds ratio = 0.27, p < 0.01), abdominal obesity (odds ratio = 0.33, p < 0.01), high blood pressure (odds ratio = 0.35, p < 0.01), hyperglycemia (odds ratio = 0.45, p < 0.05), and inflammation (odds ratio = 0.30, p = 0.01). Additionally, subjects who had a high β-carotene status with a low proportion of metabolic syndrome when they had a low-grade inflammatory status (p < 0.01). Obese OA patients suffered from a higher prevalence of metabolic syndrome and lower β-carotene status compared to the non-obese controls. A better β-carotene status (≥0.8 µM) was inversely associated with the risk of metabolic syndrome and inflammation, so we suggest that β-carotene status could be a predictor of the risk of metabolic syndrome and inflammation in patients with and without OA. View Full-Text
Keywords: β-carotene; osteoarthritis; obesity; metabolic syndrome; inflammation β-carotene; osteoarthritis; obesity; metabolic syndrome; inflammation
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MDPI and ACS Style

Yen, C.-H.; Chang, P.-S.; Chiu, C.-J.; Huang, Y.-Y.; Lin, P.-T. β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis. Nutrients 2021, 13, 2280. https://doi.org/10.3390/nu13072280

AMA Style

Yen C-H, Chang P-S, Chiu C-J, Huang Y-Y, Lin P-T. β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis. Nutrients. 2021; 13(7):2280. https://doi.org/10.3390/nu13072280

Chicago/Turabian Style

Yen, Chi-Hua, Po-Sheng Chang, Ching-Ju Chiu, Yu-Yun Huang, and Ping-Ting Lin. 2021. "β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis" Nutrients 13, no. 7: 2280. https://doi.org/10.3390/nu13072280

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