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Article

Diet Composition, Glucose Homeostasis, and Weight Regain in the YoYo Study

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
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Author to whom correspondence should be addressed.
Academic Editors: Kazushige Goto and Paul Holvoet
Nutrients 2021, 13(7), 2257; https://doi.org/10.3390/nu13072257
Received: 14 May 2021 / Revised: 14 June 2021 / Accepted: 25 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Glucose Metabolism and Weight Management)
Based on several randomized clinical trials, it has been suggested that baseline glucose homeostasis interacts with the influence of diet composition on weight loss and weight loss maintenance. In this secondary analysis of the YoYo study, a study investigating predictors of weight loss maintenance, we tested the hypothesis that (self-selected) dietary carbohydrate and/or fibre intake interact with the glucose homeostasis parameters for weight loss maintenance. Sixty-one overweight or obese individuals lost around 10 kg of body weight on an energy-restricted diet and were then followed for 9 months. During this period, participants were advised to maintain their body weight and eat a healthy diet without further recommendations on calorie intake or diet composition. Contrary to our hypothesis, carbohydrate intake showed no positive association with weight regain after weight loss, and no interaction with baseline fasting glucose concentration was found. There was a non-significant negative association between fibre intake and weight regain (B = −0.274, standard error (SE) 0.158, p = 0.090), but again, no interaction with fasting plasma glucose was found. In conclusion, the data from the YoYo study do not support a role for baseline glucose homeostasis in determining the association between self-reported carbohydrate and/or fibre intake and weight regain after weight loss. View Full-Text
Keywords: carbohydrate intake; fibre intake; fasting plasma glucose concentration; weight maintenance carbohydrate intake; fibre intake; fasting plasma glucose concentration; weight maintenance
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MDPI and ACS Style

van Baak, M.A.; Roumans, N.J.T.; Mariman, E.C.M. Diet Composition, Glucose Homeostasis, and Weight Regain in the YoYo Study. Nutrients 2021, 13, 2257. https://doi.org/10.3390/nu13072257

AMA Style

van Baak MA, Roumans NJT, Mariman ECM. Diet Composition, Glucose Homeostasis, and Weight Regain in the YoYo Study. Nutrients. 2021; 13(7):2257. https://doi.org/10.3390/nu13072257

Chicago/Turabian Style

van Baak, Marleen A., Nadia J. T. Roumans, and Edwin C. M. Mariman. 2021. "Diet Composition, Glucose Homeostasis, and Weight Regain in the YoYo Study" Nutrients 13, no. 7: 2257. https://doi.org/10.3390/nu13072257

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