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Article

Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men

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Department of Sport, Faculty of Physical Education, Kazimierz Wielki University, 85-091 Bydgoszcz, Poland
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Masdiag Sp. z o.o. Company, 01-882 Warsaw, Poland
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Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Torun, Poland
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Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdansk, Poland
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Department of Bioenergetics and Nutrition, Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Department of Health and Life Sciences, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Department of Biochemistry, Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Department of Health Sciences, Jan Dlugosz University, 42-200 Czestochowa, Poland
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Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education in Krakow, 31-571 Krakow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Carsten Carlberg
Nutrients 2021, 13(6), 1963; https://doi.org/10.3390/nu13061963
Received: 21 April 2021 / Revised: 29 May 2021 / Accepted: 4 June 2021 / Published: 8 June 2021
(This article belongs to the Section Nutrition and Metabolism)
Background: Vitamin D plays pleiotropic roles in the body and hence, changes in its metabolism and distribution during starvation could play an important role in the adaptive response to famine. We aimed to identify the responses of some vitamin D metabolites to 8 d of fasting and exercise. Methods: A repeated-measures design was implemented, in which 14 male volunteers fasted for 8 d and performed an exercise test before and after fasting. Serum samples were collected on day 1 after night fasting and after 8 d of complete food restriction, before and 1 h and 3 h after exercise. Results: After 8 d of fasting, compared with baseline values, serum 24,25(OH)2D3 and 3-epi-25(OH)D3 levels significantly increased; those of 25(OH)D3 and 1,25(OH)2D3 were unaffected; and those of 25(OH)D2 decreased. Exercise on the first day of fasting induced an increase in serum 3-epi-25(OH)D3 levels, while exercise performed after 8 d of fasting induced an increase in 25(OH)D3, 24,25(OH)2D3, 25(OH)D2, and 3-epi-25(OH)D3 levels. Conclusion: Increases in 24,25(OH)2D3 and 3-epi-25(OH)D3 levels imply that fasting stimulates vitamin D metabolism. The effects of exercise on serum vitamin D metabolites, which are most pronounced after fasting and in subjects with serum 25(OH)D3 above 25 ng/mL, support the notion that fasting and exercise augment vitamin D metabolism. View Full-Text
Keywords: food restriction; endurance exercise; 1,25(OH)2D3; 3-epi-25(OH)D3; 24,25(OH)2D3; 25(OH)D3 food restriction; endurance exercise; 1,25(OH)2D3; 3-epi-25(OH)D3; 24,25(OH)2D3; 25(OH)D3
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MDPI and ACS Style

Żychowska, M.; Rola, R.; Borkowska, A.; Tomczyk, M.; Kortas, J.; Anczykowska, K.; Pilis, K.; Kowalski, K.; Pilch, W.; Antosiewicz, J. Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men. Nutrients 2021, 13, 1963. https://doi.org/10.3390/nu13061963

AMA Style

Żychowska M, Rola R, Borkowska A, Tomczyk M, Kortas J, Anczykowska K, Pilis K, Kowalski K, Pilch W, Antosiewicz J. Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men. Nutrients. 2021; 13(6):1963. https://doi.org/10.3390/nu13061963

Chicago/Turabian Style

Żychowska, Małgorzata, Rafał Rola, Andżelika Borkowska, Maja Tomczyk, Jakub Kortas, Katarzyna Anczykowska, Karol Pilis, Konrad Kowalski, Wanda Pilch, and Jędrzej Antosiewicz. 2021. "Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men" Nutrients 13, no. 6: 1963. https://doi.org/10.3390/nu13061963

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