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Article

Is There Association between Altered Adrenergic System Activity and Microvascular Endothelial Dysfunction Induced by a 7-Day High Salt Intake in Young Healthy Individuals

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Department of Physiology and Immunology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
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Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Trg Svetog Trojstva 3, HR-31000 Osijek, Croatia
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Department of Pathophysiology, Physiology and Immunology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 10E, HR-31000 Osijek, Croatia
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Clinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, HR-31000 Osijek, Croatia
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Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
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Department of Software Engineering, Faculty of Electrical Engineering, Computer Science and Information Technology, Josip Juraj Strossmayer University of Osijek, Kneza Trpimira 2B, HR-31000 Osijek, Croatia
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Department for Cardiovascular Disease, Osijek University Hospital, J. Huttlera 4, HR-31000 Osijek, Croatia
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Department for Internal Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Belen Ponte
Nutrients 2021, 13(5), 1731; https://doi.org/10.3390/nu13051731
Received: 24 April 2021 / Revised: 12 May 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Dietary Sodium and Human Health)
This study aimed to test the effect of a 7-day high-salt (HS) diet on autonomic nervous system (ANS) activity in young healthy individuals and modulation of ANS on microvascular endothelial function impairment. 47 young healthy individuals took 7-day low-salt (LS) diet (3.5 g salt/day) followed by 7-day high-salt (HS) diet (~14.7 g salt/day). ANS activity was assessed by 24-h urine catecholamine excretion and 5-min heart rate variability (HRV). Skin post-occlusive reactive hyperemia (PORH) and acetylcholine-induced dilation (AChID) were assessed by laser Doppler flowmetry (LDF). Separately, mental stress test (MST) at LS and HS condition was conducted, followed by immediate measurement of plasma metanephrines’ level, 5-min HRV and LDF microvascular reactivity. Noradrenaline, metanephrine and normetanephrine level, low-frequency (LF) HRV and PORH and AChID significantly decreased following HS compared to LS. MST at HS condition tended to increase HRV LF/HF ratio. Spectral analysis of PORH signal, and AChID measurement showed that MST did not significantly affect impaired endothelium-dependent vasodilation due to HS loading. In this case, 7-day HS diet suppressed sympathetic nervous system (SNS) activity, and attenuated microvascular reactivity in salt-resistant normotensive individuals. Suppression of SNS during HS loading represents a physiological response, rather than direct pathophysiological mechanism by which HS diet affects microvascular endothelial function in young healthy individuals. View Full-Text
Keywords: high-salt diet; autonomic nervous system; sympathetic nervous system; heart rate variability; catecholamine; endothelium high-salt diet; autonomic nervous system; sympathetic nervous system; heart rate variability; catecholamine; endothelium
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MDPI and ACS Style

Stupin, A.; Drenjančević, I.; Šušnjara, P.; Debeljak, Ž.; Kolobarić, N.; Jukić, I.; Mihaljević, Z.; Martinović, G.; Selthofer-Relatić, K. Is There Association between Altered Adrenergic System Activity and Microvascular Endothelial Dysfunction Induced by a 7-Day High Salt Intake in Young Healthy Individuals. Nutrients 2021, 13, 1731. https://doi.org/10.3390/nu13051731

AMA Style

Stupin A, Drenjančević I, Šušnjara P, Debeljak Ž, Kolobarić N, Jukić I, Mihaljević Z, Martinović G, Selthofer-Relatić K. Is There Association between Altered Adrenergic System Activity and Microvascular Endothelial Dysfunction Induced by a 7-Day High Salt Intake in Young Healthy Individuals. Nutrients. 2021; 13(5):1731. https://doi.org/10.3390/nu13051731

Chicago/Turabian Style

Stupin, Ana, Ines Drenjančević, Petar Šušnjara, Željko Debeljak, Nikolina Kolobarić, Ivana Jukić, Zrinka Mihaljević, Goran Martinović, and Kristina Selthofer-Relatić. 2021. "Is There Association between Altered Adrenergic System Activity and Microvascular Endothelial Dysfunction Induced by a 7-Day High Salt Intake in Young Healthy Individuals" Nutrients 13, no. 5: 1731. https://doi.org/10.3390/nu13051731

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