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Article

Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice

1
Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium
2
Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Louvain Drug Research Institute, UCLouvain, B-1200 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Academic Editors: Roberta Masella and Manuel Sánchez Santos
Nutrients 2021, 13(5), 1436; https://doi.org/10.3390/nu13051436
Received: 16 March 2021 / Revised: 19 April 2021 / Accepted: 22 April 2021 / Published: 24 April 2021
(This article belongs to the Section Prebiotics and Probiotics)
Berberine and curcumin, used as food additives or food supplements, possess interesting anti-inflammatory and antioxidant properties. We tested the potential protective effect of both phytochemicals in genetically obese mice and we determined whether these effects can be related to the modulation of gut functions and microbiota. Ob/ob mice were fed a standard diet supplemented with or without 0.1% berberine and/or 0.3% curcumin for 4 weeks. By using targeted qPCR, we found that cecal content of Bifidobacterium spp. and Akkermansia spp. increased mainly upon berberine supplementation. Genes involved in innate immunity (Pla2g2a), mucus production (Muc2) and satietogenic peptide production (Gcg and Pyy) were upregulated in the colon of mice treated with both phytochemicals. Berberine supplementation alone reduced food intake, body weight gain, hypertriglyceridemia and hepatic inflammatory and oxidative stress markers, thus lessening hepatic injury. The increase in Bifidobacterium spp. and Akkermansia spp. was correlated with the improvement of gut barrier function and with the improvement of hepatic inflammatory and oxidative stresses in obese mice. These data support the fact that non-carbohydrate phytochemicals may modulate the gut microbiota in obesity and related gut and hepatic alterations. View Full-Text
Keywords: berberine; curcumin; prebiotic; gut barrier; liver injury; obesity; inflammation berberine; curcumin; prebiotic; gut barrier; liver injury; obesity; inflammation
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MDPI and ACS Style

Neyrinck, A.M.; Sánchez, C.R.; Rodriguez, J.; Cani, P.D.; Bindels, L.B.; Delzenne, N.M. Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice. Nutrients 2021, 13, 1436. https://doi.org/10.3390/nu13051436

AMA Style

Neyrinck AM, Sánchez CR, Rodriguez J, Cani PD, Bindels LB, Delzenne NM. Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice. Nutrients. 2021; 13(5):1436. https://doi.org/10.3390/nu13051436

Chicago/Turabian Style

Neyrinck, Audrey M., Cándido R. Sánchez, Julie Rodriguez, Patrice D. Cani, Laure B. Bindels, and Nathalie M. Delzenne. 2021. "Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice" Nutrients 13, no. 5: 1436. https://doi.org/10.3390/nu13051436

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