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Article

Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice

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Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil
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Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil
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Curso de Graduação em Fisioterapia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil
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Curso de Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil
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Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Pedro L. Valenzuela
Nutrients 2021, 13(4), 1177; https://doi.org/10.3390/nu13041177
Received: 22 February 2021 / Revised: 29 March 2021 / Accepted: 30 March 2021 / Published: 2 April 2021
Dry extracts from the Eurasian plants, Ajuga turkestanica, Eurycoma longifolia, and Urtica dioica have been used as anabolic supplements, despite the limited scientific data on these effects. To assess their actions on early sarcopenia signs, male and female castrated mice were supplemented with lyophilized extracts of the three plants, isolated or in association (named TLU), and submitted to resistance exercise. Ovariectomy (OVX) led to body weight increase and non-high-density cholesterol (HDL) cholesterol elevation, which had been restored by exercise plus U. dioica extract, or by exercise and TLU, respectively. Orchiectomy (ORX) caused skeletal muscle weight loss, accompanied by increased adiposity, being the latter parameter reduced by exercise plus E. longifolia or U. dioica extracts. General physical activity was improved by exercise plus herbal extracts in either OVX or ORX animals. Exercise combined with TLU improved resistance to fatigue in OVX animals, though A. turkestanica enhanced the grip strength in ORX mice. E. longifolia or TLU also reduced the ladder climbing time in ORX mice. Resistance exercise plus herbal extracts partly altered gastrocnemius fiber size frequencies in OVX or ORX mice. We provide novel data that tested ergogenic extracts, when combined with resistance exercise, improved early sarcopenia alterations in castrated male and female mice. View Full-Text
Keywords: ergogenic phytotherapics; Ajuga turkestanica; Eurycoma longifolia; Urtica dioica; resistance exercise; ovariectomy; orchiectomy; sarcopenia; aging; mice ergogenic phytotherapics; Ajuga turkestanica; Eurycoma longifolia; Urtica dioica; resistance exercise; ovariectomy; orchiectomy; sarcopenia; aging; mice
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MDPI and ACS Style

Martins, J.P.; Silva, L.C.; Nunes, M.S.; Rübensam, G.; Oliveira, J.R.; Silva, R.B.M.; Campos, M.M. Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice. Nutrients 2021, 13, 1177. https://doi.org/10.3390/nu13041177

AMA Style

Martins JP, Silva LC, Nunes MS, Rübensam G, Oliveira JR, Silva RBM, Campos MM. Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice. Nutrients. 2021; 13(4):1177. https://doi.org/10.3390/nu13041177

Chicago/Turabian Style

Martins, Jerônimo P., Lucia C. Silva, Matheus S. Nunes, Gabriel Rübensam, Jarbas R. Oliveira, Rodrigo B.M. Silva, and Maria M. Campos 2021. "Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice" Nutrients 13, no. 4: 1177. https://doi.org/10.3390/nu13041177

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