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Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety

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Department of Pediatric Hematology and Oncology, University Children’s Hospital, University Medical Centre Ljubljana, Bohoričeva ulica 20, 1000 Ljubljana, Slovenia
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The Chair of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Victoria Arija Val
Nutrients 2021, 13(4), 1087; https://doi.org/10.3390/nu13041087
Received: 10 February 2021 / Revised: 23 March 2021 / Accepted: 24 March 2021 / Published: 26 March 2021
(This article belongs to the Section Nutrition and Public Health)
A major problem of oral iron supplementation efficacy in children is its tolerability and compliance. We aimed to determine the safety and efficacy of a novel food supplement >Your< Iron Syrup in the replenishment of iron stores and improvement of hematological parameters in iron-deficient children aged nine months to six years. We randomized 94 healthy children with iron deficiency in a ratio of 3:1 to either receive >Your< Iron Syrup or placebo. A 12-week supplementation with >Your< Iron Syrup resulted in a significant increase in ferritin and hemoglobin levels as compared to placebo (p = 0.04 and p = 0.02). Adverse events were reported with similar frequencies across both study arms. >Your< Iron Syrup represents an effective, well-tolerated, and safe option for the management of nutritional iron deficiency in children. View Full-Text
Keywords: iron deficiency; pediatric; children; supplementation; microencapsulated iron; syrup; liquid; food supplement iron deficiency; pediatric; children; supplementation; microencapsulated iron; syrup; liquid; food supplement
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MDPI and ACS Style

Zečkanović, A.; Kavčič, M.; Prelog, T.; Šmid, A.; Jazbec, J. Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety. Nutrients 2021, 13, 1087. https://doi.org/10.3390/nu13041087

AMA Style

Zečkanović A, Kavčič M, Prelog T, Šmid A, Jazbec J. Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety. Nutrients. 2021; 13(4):1087. https://doi.org/10.3390/nu13041087

Chicago/Turabian Style

Zečkanović, Aida, Marko Kavčič, Tomaž Prelog, Alenka Šmid, and Janez Jazbec. 2021. "Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety" Nutrients 13, no. 4: 1087. https://doi.org/10.3390/nu13041087

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