The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa

Monteleone, Alessio Maria; Troisi, Jacopo; Serena, Gloria; Fasano, Alessio; Dalle Grave, Riccardo; Cascino, Giammarco; Marciello, Francesca; Calugi, Simona; Scala, Giovanni; Corrivetti, Giulio; Monteleone, Palmiero

doi:10.3390/nu13020507

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The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa

Alessio Maria Monteleone

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Department of Psychiatry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

Theoreo srl, Via Degli Ulivi 3, 84090 Montecorvino Pugliano, Italy

European Biomedical Research Institute of Salerno (EBRIS), Via S. De Renzi, 3, 84125 Salerno, Italy

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Mucosal Immunology and Biology Research Center, Massachusetts General Hospital—Harvard Medical School, Boston, MA 02114, USA

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Department of Eating and Weight Disorders, Villa Garda Hospital, Garda, 37016 Verona, Italy

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Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, 84081 Baronissi, Italy

Author to whom correspondence should be addressed.

Academic Editor: Beate Herpertz-Dahlmann

Nutrients 2021, 13(2), 507; https://doi.org/10.3390/nu13020507

Received: 28 December 2020 / Revised: 23 January 2021 / Accepted: 31 January 2021 / Published: 4 February 2021

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Abstract

Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and metabolomics profiles of 17 ANR women, six ANBP women and 20 healthy controls (HC). Twelve fecal metabolites differentiating ANR patients, ANBP patients and HC were identified. Both patient groups showed decreased intra-individual bacterial richness with respect to healthy controls (HC). Compared to ANR subjects, ANBP patients had a significant increase in relative abundances of Bifidobacterium, Bifidobacteriaceae, Bifidobacteriales, and Eubacteriacae and a significant decrease in relative abundances of Odoribacter, Haemophilus, Pasteurellaceae, and Pasteurellales. The heatmaps of the relationships of selected fecal metabolites with microbial families showed different structures among the three groups, with the heatmap of ANBP patients being drastically different from that of HC, while that of ANR patients resulted more similar to HC. These findings, although preliminary because of the relatively small sample size, confirm the occurrence of different gut dysbiosis in ANR and ANBP and demonstrate different connections between gut microorganisms and fecal metabolites in the two AN types. View Full-Text

Keywords: restricting anorexia nervosa; binge-purging anorexia nervosa; eating disorders; gut microbiome; fecal metabolomics

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Monteleone, A.M.; Troisi, J.; Serena, G.; Fasano, A.; Dalle Grave, R.; Cascino, G.; Marciello, F.; Calugi, S.; Scala, G.; Corrivetti, G.; Monteleone, P. The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa. Nutrients 2021, 13, 507. https://doi.org/10.3390/nu13020507

AMA Style

Monteleone AM, Troisi J, Serena G, Fasano A, Dalle Grave R, Cascino G, Marciello F, Calugi S, Scala G, Corrivetti G, Monteleone P. The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa. Nutrients. 2021; 13(2):507. https://doi.org/10.3390/nu13020507

Chicago/Turabian Style

Monteleone, Alessio M., Jacopo Troisi, Gloria Serena, Alessio Fasano, Riccardo Dalle Grave, Giammarco Cascino, Francesca Marciello, Simona Calugi, Giovanni Scala, Giulio Corrivetti, and Palmiero Monteleone. 2021. "The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa" Nutrients 13, no. 2: 507. https://doi.org/10.3390/nu13020507

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