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Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

1
Department of Clinical Nutrition, General Hospital Korgialenio Benakio, 11526 Athens, Greece
2
Laboratory of Biochemistry, Faculty of Chemistry, National & Kapodistrian University of Athens, 16121 Athens, Greece
3
Laboratory of Biology, Biochemistry and Microbiology, Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Street, 17671 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Mario Barbagallo
Nutrients 2021, 13(2), 462; https://doi.org/10.3390/nu13020462
Received: 29 December 2020 / Revised: 23 January 2021 / Accepted: 26 January 2021 / Published: 30 January 2021
(This article belongs to the Section Micronutrients and Human Health)
The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated. The disease is directly connected to the nutritional status of patients and a well-balanced diet is recommended by official sources. Recently, the role of platelet activating factor (PAF) was suggested in the pathogenesis of COVID-19. In the present review several micronutrients (vitamin A, vitamin C, vitamin E, vitamin D, selenium, omega-3 fatty acids, and minerals), phytochemicals and Mediterranean diet compounds with potential anti-COVID activity are presented. We further underline that the well-known anti-inflammatory and anti-thrombotic actions of the investigated nutrients and/or holistic dietary schemes, such as the Mediterranean diet, are also mediated through PAF. In conclusion, there is no single food to prevent coronavirus Although the relationship between PAF and COVID-19 is not robust, a healthy diet containing PAF inhibitors may target both inflammation and thrombosis and prevent the deleterious effects of COVID-19. The next step is the experimental confirmation or not of the PAF-COVID-19 hypothesis. View Full-Text
Keywords: platelet activating factor; thrombosis; inflammation; Mediterranean diet; PAF-inhibitors platelet activating factor; thrombosis; inflammation; Mediterranean diet; PAF-inhibitors
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MDPI and ACS Style

Detopoulou, P.; Demopoulos, C.A.; Antonopoulou, S. Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism. Nutrients 2021, 13, 462. https://doi.org/10.3390/nu13020462

AMA Style

Detopoulou P, Demopoulos CA, Antonopoulou S. Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism. Nutrients. 2021; 13(2):462. https://doi.org/10.3390/nu13020462

Chicago/Turabian Style

Detopoulou, Paraskevi; Demopoulos, Constantinos A.; Antonopoulou, Smaragdi. 2021. "Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism" Nutrients 13, no. 2: 462. https://doi.org/10.3390/nu13020462

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