Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Measurements of Serum 25(OH)D and PTH
2.3. Covariates
2.4. Statistical Analyses
3. Results
3.1. General Characteristics of the Studied Population
3.2. PTH Concentrations by Pregnancy Trimester, Country of Origin, Serum Vitamin D Levels, and Season
3.3. Determinants of PTH Concentrations: Multiple Regression Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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1st Trimester | 3rd Trimester | Missing n (%) | |||
---|---|---|---|---|---|
n (%) | 204 | 50.12 | 203 | 49.88 | |
PTH ng/L, median (Q1, Q3) | 22.75 | 16.9, 28.6 | 25.7 | 18.8, 36.6 | |
25(OH)D ng/mL, median (Q1, Q3) | 17.1 | 9.75, 22.3 | 17.9 | 11.9, 28.1 | |
25(OH)D nmol/L, median (Q1, Q3) | 42.8 | 24.4, 55.8 | 44.8 | 29.8, 70.3 | |
Vitamin D deficiency, n (%) | 129 | 63.24 | 111 | 54.68 | |
Skin color, n (%) * | 1 (0.25) | ||||
Light | 151 | 74.02 | 173 | | 85.64 | |
Dark | 53 | 25.98 | 29 | 14.36 | |
Melanin levels, median (Q1, Q3) | 36.45 | 30.2–39.58 | 32.94 | 29.35–34.67 | 2 (0.49) |
Age, mean (SD) | 30.20 | 4.85 | 33.59 | 5.06 | |
Week of pregnancy, median (Q1, Q3) | 8 | 7.59 | 38 | 38.38 | |
Parity, n (%) nulliparous | 108 | 52.94 | 60 | 29.56 | |
Gravidity, n (%) first pregnancy | 84 | 41.18 | 51 | 25.12 | |
BMI (kg/m2) before pregnancy, median (Q1, Q3) | 22.90 | 19.94, 24.87 | 24.30 | 21.23, 25.71 | 23 (5.65) |
BMI (kg/m2) current, median (Q1, Q3) | 23.17 | 20.42, 25.74 | 29.00 | 25.59, 30.85 | 6 (1.47) |
Country of origin, n (%) | 2 (0.49) | ||||
Switzerland and Germany | 44 | 21.57 | 67 | 33.3 | |
North America and Europe, Caucasus, Central Asia, and New Zealand (without Switzerland and Germany) | 63 | 30.88 | 62 | 30.85 | |
South Europe, Australia, Latin America, and the Caribbean | 30 | 14.71 | 30 | 14.93 | |
South and East Asia, Pacific | 32 | 15.69 | 18 | 8.96 | |
Africa, and the Middle East | 35 | 17.16 | 24 | 11.94 | |
Educational level achieved, n (%) | 1 (0.25) | ||||
Less than compulsory education | 13 | 6.37 | 9 | 4.46 | |
Low education | 21 | 10.29 | 31 | 15.35 | |
Middle education | 67 | 32.84 | 64 | 31.68 | |
High education | 103 | 50.49 | 98 | 48.51 | |
Educational level achieved of the partner, n (%) | 11 (2.07) | ||||
Less than compulsory education | 14 | 6.93 | 11 | 5.67 | |
Low education | 21 | 10.4 | 19 | 9.79 | |
Middle education | 77 | 38.12 | 71 | 36.6 | |
High education | 90 | 44.55 | 93 | 47.94 | |
Smoking status, n (%) | 3 (0.74) | ||||
Never smoker | 121 | 59.31 | 122 | 60.4 | |
Ever smoker | 62 | 30.39 | 61 | 30.2 | |
Current smoker | 21 | 10.3 | 19 | 9.41 | |
Season, n (%) | 3 (0.74) | ||||
Winter | 39 | 19.1 | 64 | 32 | |
Spring | 46 | 22.55 | 78 | 39 | |
Summer | 50 | 24.5 | 18 | 9 | |
Fall | 69 | 33.82 | 40 | 20 | |
Days per week spent at least 1 h outdoor (Q1, Q3) | 2 | 2, 7 | 4 | 2, 7 | 8 (1.97) |
Using sun protection in summer, n (%) | 2 (0.49) | ||||
Never | 50 | 24.63 | 42 | 20.79 | |
Sometimes | 75 | 38.42 | 81 | 40.1 | |
Always | 78 | 36.95 | 79 | 39.11 | |
Fish consumption at least once per week, % | 96 | 47.52 | 109 | 54.23 | 6 (1.47) |
Vitamin D supplement intake, n (%) | 17 | 8.33 | 32 | 15.76 | |
Multivitamin supplement intake, n (%) | 86 | 42.16 | 127 | 62.56 | |
Iron supplement intake, n (%) | 28 | 14.07 | 96 | 60 | 48 (11.8) |
Factors | Coef. * | 95% CI | |
---|---|---|---|
Log 25(OH)D l | −0.289 | −0.401 | −0.178 |
Age | 0.010 | −0.002 | 0.022 |
Country of origin | |||
Switzerland and Germany | ref | ||
North America and Europe, Caucasus, Central Asia, and New Zealand (without Switzerland and Germany) | 0.018 | −0.128 | 0.165 |
South Europe, Australia, Latin America, and the Caribbean | −0.030 | −0.205 | 0.145 |
South and East Asia and the Pacific | −0.047 | −0.243 | 0.149 |
Africa and the Middle East | −0.176 | −0.371 | 0.019 |
Education 1 | |||
Less than compulsory education | ref | ||
Low education | −0.241 | −0.506 | 0.024 |
Middle education | −0.405 | −0.644 | −0.166 |
High education | −0.378 | −0.625 | −0.131 |
Nulliparity | |||
Yes | ref | ||
No | 0.166 | 0.057 | 0.274 |
Days per week spent at least 1 h outdoor | 0.020 | 0.001 | 0.039 |
BMI | 0.004 | −0.008 | 0.017 |
Multivitamin supplementation | −0.081 | −0.195 | 0.034 |
Season | |||
Winter | ref | ||
Spring | 0.165 | 0.002 | 0.327 |
Summer | 0.098 | −0.061 | 0.257 |
Autumn | 0.093 | −0.054 | 0.239 |
Factors | Coef. * | [95% CI] | |
---|---|---|---|
Log 25(OH)D | −0.277 | −0.404 | −0.149 |
Age | 0.003 | −0.012 | 0.017 |
Country of origin | |||
Switzerland and Germany | ref | ||
North America and Europe, Caucasus, Central Asia, and New Zealand (without Switzerland and Germany) | −0.022 | −0.201 | 0.157 |
South Europe, Australia, Latin America, and the Caribbean | 0.043 | −0.178 | 0.264 |
South and East Asia and the Pacific | −0.103 | −0.365 | 0.159 |
Africa and the Middle East | −0.246 | −0.491 | −0.01 |
Education 1 | |||
Less than compulsory education | ref | ||
Low education | 0.036 | −0.353 | 0.425 |
Middle education | −0.103 | −0.433 | 0.227 |
High education | −0.015 | −0.352 | 0.322 |
Sun protection | |||
Never | ref | ||
Sometimes | −0.111 | −0.314 | 0.092 |
Always | −0.116 | −0.323 | 0.091 |
BMI | −0.002 | −0.017 | 0.013 |
Season | |||
Winter | ref | ||
Spring | −0.056 | −0.229 | 0.116 |
Summer | 0.102 | −0.169 | 0.372 |
Autumn | 0.055 | −0.146 | 0.256 |
Iron supplementation | 0.095 | −0.071 | 0.261 |
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Hysaj, O.; Marqués-Gallego, P.; Richard, A.; Elgizouli, M.; Nieters, A.; Quack Lötscher, K.C.; Rohrmann, S. Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants. Nutrients 2021, 13, 360. https://doi.org/10.3390/nu13020360
Hysaj O, Marqués-Gallego P, Richard A, Elgizouli M, Nieters A, Quack Lötscher KC, Rohrmann S. Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants. Nutrients. 2021; 13(2):360. https://doi.org/10.3390/nu13020360
Chicago/Turabian StyleHysaj, Ola, Patricia Marqués-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lötscher, and Sabine Rohrmann. 2021. "Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants" Nutrients 13, no. 2: 360. https://doi.org/10.3390/nu13020360
APA StyleHysaj, O., Marqués-Gallego, P., Richard, A., Elgizouli, M., Nieters, A., Quack Lötscher, K. C., & Rohrmann, S. (2021). Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants. Nutrients, 13(2), 360. https://doi.org/10.3390/nu13020360