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Open AccessArticle

Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa–Exploratory Study

1
Chair of Public Health, Medical University of Lublin, 20-090 Lublin, Poland
2
Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland
3
Laboratory of Cellular and Molecular Pharmacology, Chair and Department of Experimental and Clinical Pharmacology, Medical University of Lublin, 20-090 Lublin, Poland
4
Chair and Department of Experimental and Clinical Pharmacology, Medical University of Lublin, 20-090 Lublin, Poland
5
Department of Clinical Genetics, Medical University of Lublin, 20-090 Lublin, Poland
6
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, Poland
7
Department of Virology and Immunology, Maria Curie-Skłodowska University of Lublin, 20-033 Lublin, Poland
8
Department of General Ophthalmology, Medical University of Lublin, 20-400 Lublin, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(2), 339; https://doi.org/10.3390/nu13020339
Received: 15 November 2020 / Revised: 20 January 2021 / Accepted: 20 January 2021 / Published: 24 January 2021
The link between the kynurenine pathway and immunomodulatory molecules—fractalkine and soluble intercellular adhesion molecule-1 (sICAM-1)—in anorexia nervosa (AN) remains unknown. Fractalkine, sICAM-1, tryptophan (TRP), kynurenine (KYN), neuroprotective kynurenic acid (KYNA), neurotoxic 3-OH-kynurenine (3-OH-KYN), and the expression of mRNA for kynurenine aminotransferases (KAT1-3) were studied in 20 female patients with restrictive AN (mostly drug-free, all during first episode of the disease) and in 24 controls. In AN, serum fractalkine, but not sICAM-1, KYNA, KYN, TRP or 3-OH-KYN, was higher; ratios TRP/KYN, KYN/KYNA, KYN/3-OH-KYN and KYNA/3-OH-KYN were unaltered. The expression of the gene encoding KAT3, but not of genes encoding KAT1 and KAT2 (measured in blood mononuclear cells), was higher in patients with AN. In AN, fractalkine positively correlated with TRP, while sICAM-1 was negatively associated with 3-OH-KYN and positively linked with the ratio KYN/3-OH-KYN. Furthermore, TRP and fractalkine were negatively associated with the body mass index (BMI) in AN. Expression of KAT1, KAT2 and KAT3 did not correlate with fractalkine, sICAM-1 or BMI, either in AN or control. Increased fractalkine may be an independent factor associated with the restrictive type of AN. Excessive physical activity probably underlies increased expression of KAT3 observed among enrolled patients. Further, longitudinal studies on a larger cohort of patients should be aimed to clarify the contribution of fractalkine and KAT3 to the pathogenesis of AN. View Full-Text
Keywords: eating disorders; neuroprotection; neurotoxicity; kynurenine eating disorders; neuroprotection; neurotoxicity; kynurenine
MDPI and ACS Style

Dudzińska, E.; Szymona, K.; Kloc, R.; Kocki, T.; Gil-Kulik, P.; Bogucki, J.; Kocki, J.; Paduch, R.; Urbańska, E.M. Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa–Exploratory Study. Nutrients 2021, 13, 339. https://doi.org/10.3390/nu13020339

AMA Style

Dudzińska E, Szymona K, Kloc R, Kocki T, Gil-Kulik P, Bogucki J, Kocki J, Paduch R, Urbańska EM. Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa–Exploratory Study. Nutrients. 2021; 13(2):339. https://doi.org/10.3390/nu13020339

Chicago/Turabian Style

Dudzińska, Ewa; Szymona, Kinga; Kloc, Renata; Kocki, Tomasz; Gil-Kulik, Paulina; Bogucki, Jacek; Kocki, Janusz; Paduch, Roman; Urbańska, Ewa M. 2021. "Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa–Exploratory Study" Nutrients 13, no. 2: 339. https://doi.org/10.3390/nu13020339

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