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Open AccessArticle

Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population

1
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore
2
Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, Singapore 119228, Singapore
3
Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2603; https://doi.org/10.3390/nu12092603
Received: 20 July 2020 / Revised: 23 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
(This article belongs to the Section Nutrition and Metabolism)
Profiles of circulating amino acids have been associated with cardiometabolic diseases. We investigated the associations between dietary protein intake, physical activity and adiposity and serum amino acid profiles in an Asian population. We used data from 3009 male and female participants from the Singapore Prospective Study Program cohort. Dietary and physical activity data were obtained from validated questionnaires; anthropometric measurements were collected during a health examination; and fasting concentrations of 16 amino acids were measured using targeted LC-MS. The association between lifestyle factors and amino acid levels was modeled using multiple linear regression with adjustment for other sociodemographic and lifestyle factors and correction for multiple testing. We observed significant associations between seafood intake (β-coefficient 0.132, 95% CI 0.006, 0.257 for a 100% increment), physical activity (β-coefficient −0.096, 95% CI −0.183, −0.008 in the highest versus lowest quartile) and adiposity (BMI β-coefficient 0.062, 95% CI 0.054, 0.070 per kg/m2; waist circumference β-coefficient 0.034, 95% CI 0.031, 0.037 per cm) and branched-chain amino acid levels (expressed per-SD). We also observed significant interactions with sex for the association between meat and seafood and total intakes and BCAA levels (P for interaction 0.007), which were stronger in females than in males. Our findings suggest novel associations between modifiable lifestyle factors and amino acid levels in Asian populations. View Full-Text
Keywords: branched-chain amino acids; dietary protein source and intake; metabolomics branched-chain amino acids; dietary protein source and intake; metabolomics
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MDPI and ACS Style

Gunther, S.H.; Khoo, C.M.; Sim, X.; Tai, ES.; van Dam, R.M. Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population. Nutrients 2020, 12, 2603. https://doi.org/10.3390/nu12092603

AMA Style

Gunther SH, Khoo CM, Sim X, Tai ES, van Dam RM. Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population. Nutrients. 2020; 12(9):2603. https://doi.org/10.3390/nu12092603

Chicago/Turabian Style

Gunther, Samuel H.; Khoo, Chin M.; Sim, Xueling; Tai, E S.; van Dam, Rob M. 2020. "Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population" Nutrients 12, no. 9: 2603. https://doi.org/10.3390/nu12092603

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