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Nutrition and Fitness: Mental Health
 
 
Article

Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway

1
School of Life Science, Jiangsu Normal University, No.101, Shanghai Road, Tongshan New Area, Xuzhou 221116, China
2
College of Chemical Engineering, Sichuan University of Science and Engineering, Xuyuan Road, Zigong 643000, China
3
College of Physical Education, Jiangsu Normal University, No.101, Shanghai Road, Tongshan New Area, Xuzhou 221116, China
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1805; https://doi.org/10.3390/nu12061805
Received: 21 April 2020 / Revised: 8 June 2020 / Accepted: 16 June 2020 / Published: 17 June 2020
(This article belongs to the Section Nutrition and Public Health)
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential neuroprotective properties. Here we examined the protective effects of GAS against lead(Pb)-induced nerve injury in mice, and explores its underlying mechanisms. Our research findings revealed that GAS improved behavioral deficits in Pb-exposed mice. GAS reduced the accumulation of p-tau and amyloid-beta (Aβ). GAS inhibited Pb-induced inflammation in the brain, as indicated by the decreased levels of pro-inflammatory cytokines, including tumor necrosis factor-a (TNF-α), cyclooxygenase-2 (COX-2). GAS increased the expression levels of NR2A and neurotrophin brain-derived neurotrophic factor (BDNF). GAS inhibited Pb-induced apoptosis of neurons in hippocampus tissue, as indicated by the decreased levels of pro-apoptotic proteins Bax and cleaved caspase-3. Furthermore, the neuroprotective effects of GAS were associated with inhibiting oxidative stress by modulating nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated antioxidant signaling. GAS supplement activated the Wnt/β-catenin signaling pathway and reduced the expression of Wnt inhibitor Dickkopf-1 (Dkk-1). Collectively, this study clarified that GAS exhibited neuroprotective property by anti-oxidant, anti-inflammatory and anti-apoptosis effects and its ability to regulate the Wnt/Nrf2 pathway. View Full-Text
Keywords: gastrodin; lead; Wnt; Nrf2; inflammation; apoptosis gastrodin; lead; Wnt; Nrf2; inflammation; apoptosis
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MDPI and ACS Style

Liu, C.-M.; Tian, Z.-K.; Zhang, Y.-J.; Ming, Q.-L.; Ma, J.-Q.; Ji, L.-P. Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway. Nutrients 2020, 12, 1805. https://doi.org/10.3390/nu12061805

AMA Style

Liu C-M, Tian Z-K, Zhang Y-J, Ming Q-L, Ma J-Q, Ji L-P. Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway. Nutrients. 2020; 12(6):1805. https://doi.org/10.3390/nu12061805

Chicago/Turabian Style

Liu, Chan-Min, Zhi-Kai Tian, Yu-Jia Zhang, Qing-Lei Ming, Jie-Qiong Ma, and Li-Ping Ji. 2020. "Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway" Nutrients 12, no. 6: 1805. https://doi.org/10.3390/nu12061805

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