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A Preliminary Study for Evaluating the Dose-Dependent Effect of d-Allulose for Fat Mass Reduction in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Trial

Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea
Food R&D, CJ Cheiljedang Corp., 55, Gwanggyo-ro 42beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do 16495, Korea
Author to whom correspondence should be addressed.
Nutrients 2018, 10(2), 160;
Received: 14 December 2017 / Revised: 26 January 2018 / Accepted: 29 January 2018 / Published: 31 January 2018
PDF [699 KB, uploaded 6 February 2018]


d-allulose is a rare sugar with zero energy that can be consumed by obese/overweight individuals. Many studies have suggested that zero-calorie d-allulose has beneficial effects on obesity-related metabolism in mouse models, but only a few studies have been performed on human subjects. Therefore, we performed a preliminary study with 121 Korean subjects (aged 20–40 years, body mass index ≥ 23 kg/m2). A randomized controlled trial involving placebo control (sucralose, 0.012 g × 2 times/day), low d-allulose (d-allulose, 4 g × 2 times/day), and high d-allulose (d-allulose, 7 g × 2 times/day) groups was designed. Parameters for body composition, nutrient intake, computed tomography (CT) scan, and plasma lipid profiles were assessed. Body fat percentage and body fat mass were significantly decreased following d-allulose supplementation. The high d-allulose group revealed a significant decrease in not only body mass index (BMI), but also total abdominal and subcutaneous fat areas measured by CT scans compared to the placebo group. There were no significant differences in nutrient intake, plasma lipid profiles, markers of liver and kidney function, and major inflammation markers among groups. These results provide useful information on the dose-dependent effect of d-allulose for overweight/obese adult humans. Based on these results, the efficacy of d-allulose for body fat reduction needs to be validated using dual energy X-ray absorption. View Full-Text
Keywords: d-allulose; sugar substitutes; obesity; randomized-controlled trial d-allulose; sugar substitutes; obesity; randomized-controlled trial

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Han, Y.; Kwon, E.-Y.; Yu, M.K.; Lee, S.J.; Kim, H.-J.; Kim, S.-B.; Kim, Y.H.; Choi, M.-S. A Preliminary Study for Evaluating the Dose-Dependent Effect of d-Allulose for Fat Mass Reduction in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2018, 10, 160.

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