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Open AccessArticle

Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 625014, China
Department of Animal Husbandry and Veterinary Medicine, Chengdu Agricultural College, Chengdu 611100, China
College of Life and Biology Science, Sichuan Agricultural University, Chengdu 611130, China
Chongqing Academy of Animal Science, Chongqing 402460, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 131;
Received: 30 November 2017 / Revised: 7 January 2018 / Accepted: 18 January 2018 / Published: 26 January 2018
Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease, certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine is a nontoxic, chemically stable and naturally occurring molecule. This study shows that dietary betaine supplementation significantly inhibits the white fat production in a high-fat diet (HFD)-induced obese mice. This might be due to betaine preventing the formation of new white fat (WAT), and guiding the original WAT to burn through stimulated mitochondrial biogenesis and promoting browning of WAT. Furthermore, dietary betaine supplementation decreases intramyocellular lipid accumulation in HFD-induced obese mice. Further analysis shows that betaine supplementation reduced intramyocellular lipid accumulation might be associated with increasing polyunsaturated fatty acids (PUFA), fatty acid oxidation, and the inhibition of fatty acid synthesis in muscle. Notably, by performing insulin-tolerance tests (ITTs) and glucose-tolerance tests (GTTs), dietary betaine supplementation could be observed for improvement of obesity and non-obesity induced insulin resistance. Together, these findings could suggest that inhibiting WAT production, intramyocellular lipid accumulation and inflammation, betaine supplementation limits HFD-induced obesity and improves insulin resistance. View Full-Text
Keywords: betaine; obesity; WAT; insulin resistance; intramyocellular lipids betaine; obesity; WAT; insulin resistance; intramyocellular lipids
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Du, J.; Shen, L.; Tan, Z.; Zhang, P.; Zhao, X.; Xu, Y.; Gan, M.; Yang, Q.; Ma, J.; Jiang, A.; Tang, G.; Jiang, Y.; Jin, L.; Li, M.; Bai, L.; Li, X.; Wang, J.; Zhang, S.; Zhu, L. Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet. Nutrients 2018, 10, 131.

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