Immunity-Enhancing Effect of Extracts Extracted from Leaves of Rubia hexaphylla, Cymbopogon citratus, and Dioscorea japonica for Sustainable Healthy Life
Round 1
Reviewer 1 Report
It is a paper that studies the possibility of immune increase by natural products in the COVID-19 era and is considered a necessary study.
In this manuscript, the authors suggested that Extracts extracted from leaves of Rubia hexaphylla, Cymbopogon Citratus, and Dioscorea japonica increased the immunity. According to the data presented, their claim seems to be sound. The data brought by this article are valuable because of the relative paucity of information available on that topic. Therefore, it is considered that there are sufficient reasons for this paper to be published in the Sustainability journal.
Author Response
Dear Reviewer,
Thanks for the reviewer comments for our paper.
Your comments have been reflected as faithfully as possible.
After reviewing, if you comment on the areas that need improvement, we will revise and supplement them.
Thank you.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
1) Experimental Methods paragraph 2.1 is unclear, with different mistakes, and should be completely re-writen :
- line 66 : super-critical : I assume it is sub-critical
- line 82-84 : paste of line 79-80 (mistake)
- Indicate precisely temperature, pressure, nature and solvent ratio and yield for each extract
2) Chemical composition of the different extracts should be investigated, extraction method and raw material are not enough to characterize the products. At least, major constituants or specific markers should be identified and quantified.
3) The different activities of the 3 extracts should be compared according to their chemical composition, to have a better understanding of the activity difference and mechanism of action.
Author Response
Dear Reviewer,
Thanks for the reviewer comments for our paper.
Your comments have been reflected as faithfully as possible.
After reviewing, if you comment on the areas that need improvement, we will revise and supplement them.
thank you.
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
Experimental conditions for RCD 1 extract is not described (T, P , yield)
Author Response
We are sorry that the comments were not reflected properly.
There was a mistake in the editing process.
Comments have been supplemented as faithfully as possible.
Thank you.
Author Response File: Author Response.pdf
