Severe Nephritis as Initial Sign of Waldenström’s Macroglobulinemia
by
Thomas Knoop
1,2, 
Kristin Kampevold Larsen
3,
Friedemann Leh
3,
Anette Lodvir Hemsing
1,
Ingrid Anna Teigen
4 and
Håkon Reikvam
1,5,* 1
Department of Medicine, Haukeland University Hospital, Bergen, Norway
2
Institute of Medical Science, University of Bergen, Bergen, Norway
3
Department of Pathology, Haukeland University Hospital, Bergen, Norway
4
Department of Pharmacology, Haukeland University Hospital, Bergen, Norway
5
Institute of Clinical Science, University of Bergen, Bergen, Norway
*
Author to whom correspondence should be addressed.
Clin. Pract. 2019, 9(4), 1184; https://doi.org/10.4081/cp.2019.1184
Submission received: 9 July 2019
/
Revised: 7 November 2019
/
Accepted: 11 November 2019
/
Published: 19 December 2019
Abstract
Waldenström’s macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.
Keywords:
nephrite; hypertension; proteinuria; Waldenström’s macroglobulinemia
Share and Cite
MDPI and ACS Style
Knoop, T.; Larsen, K.K.; Leh, F.; Hemsing, A.L.; Teigen, I.A.; Reikvam, H. Severe Nephritis as Initial Sign of Waldenström’s Macroglobulinemia. Clin. Pract. 2019, 9, 1184. https://doi.org/10.4081/cp.2019.1184
AMA Style
Knoop T, Larsen KK, Leh F, Hemsing AL, Teigen IA, Reikvam H. Severe Nephritis as Initial Sign of Waldenström’s Macroglobulinemia. Clinics and Practice. 2019; 9(4):1184. https://doi.org/10.4081/cp.2019.1184
Chicago/Turabian StyleKnoop, Thomas, Kristin Kampevold Larsen, Friedemann Leh, Anette Lodvir Hemsing, Ingrid Anna Teigen, and Håkon Reikvam. 2019. "Severe Nephritis as Initial Sign of Waldenström’s Macroglobulinemia" Clinics and Practice 9, no. 4: 1184. https://doi.org/10.4081/cp.2019.1184
