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Clinics and Practice
Volume 9
Issue 2
10.4081/cp.2019.1146
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Non-Traumatic Splenic Rupture in Amyloidosis as a Rare Evolution of Multiple Myeloma

by
Lorenzo Perrone
1,2,
Lorenzo Gervaso
1,2,
Eugenia Bosco
1,2,
Francesco Serra
1,2 and
Erica Quaquarini
1,3,*
1
Department of Oncology, Maugeri Clinical and Scientific Institutes (IRCCS), Pavia, Italy
2
Department of Internal Medicine, University of Pavia, Pavia, Italy
3
PhD Program in Experimental Medicine, University of Pavia, Pavia, Italy
*
Author to whom correspondence should be addressed.
Clin. Pract. 2019, 9(2), 1146; https://doi.org/10.4081/cp.2019.1146
Submission received: 5 March 2019 / Revised: 5 March 2019 / Accepted: 17 April 2019 / Published: 7 May 2019

Abstract

We report the case of a 64-year-old man with a diagnosis of IgG lambda multiple myeloma (MM) symptomatic for bone lesions for which he received autologous stem cell transplant after induction treatment and high-dose melphalan, thalidomide and lenalidomide therapy. Twelve years after the diagnosis, he had an unexpected and acute onset of abdominal pain with signs of hypovolemic shock. A computed tomography scan was immediately performed and demonstrated a splenic rupture. A splenectomy was performed but, a week after, the patient developed an acute respiratory distress syndrome and died. After histological exam of the spleen, non-traumatic spleen rupture due to amyloidosis was our final diagnosis. This event is potentially fatal and rare in patients with MM; clinicians should be aware of this potential course of the disease and monitor patients also for amyloid induced organ damages.
Keywords: splenic rupture; amyloid light chain amyloidosis; multiple myeloma splenic rupture; amyloid light chain amyloidosis; multiple myeloma

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MDPI and ACS Style

Perrone, L.; Gervaso, L.; Bosco, E.; Serra, F.; Quaquarini, E. Non-Traumatic Splenic Rupture in Amyloidosis as a Rare Evolution of Multiple Myeloma. Clin. Pract. 2019, 9, 1146. https://doi.org/10.4081/cp.2019.1146

AMA Style

Perrone L, Gervaso L, Bosco E, Serra F, Quaquarini E. Non-Traumatic Splenic Rupture in Amyloidosis as a Rare Evolution of Multiple Myeloma. Clinics and Practice. 2019; 9(2):1146. https://doi.org/10.4081/cp.2019.1146

Chicago/Turabian Style

Perrone, Lorenzo, Lorenzo Gervaso, Eugenia Bosco, Francesco Serra, and Erica Quaquarini. 2019. "Non-Traumatic Splenic Rupture in Amyloidosis as a Rare Evolution of Multiple Myeloma" Clinics and Practice 9, no. 2: 1146. https://doi.org/10.4081/cp.2019.1146

APA Style

Perrone, L., Gervaso, L., Bosco, E., Serra, F., & Quaquarini, E. (2019). Non-Traumatic Splenic Rupture in Amyloidosis as a Rare Evolution of Multiple Myeloma. Clinics and Practice, 9(2), 1146. https://doi.org/10.4081/cp.2019.1146

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