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Clinics and Practice
Volume 5
Issue 3
10.4081/cp.2015.780
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could Be the Role of Rivastigmine? A Case Series

by
Audrey Monica van Schaik
1,*,
Didi Rhebergen
1,2,
Marieke Jantien Henstra
3,
Daniel J. Kadouch
4,
Eric van Exel
2 and
Maximilianus Lourentius Stek
2
1
GGZ inGeest, Amsterdam, The Netherlands
2
Department of Psychiatry and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
3
Department of Internal Medicine, Section of Geriatric Medicine, VU University Medical Center, Amsterdam, The Netherlands
4
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Clin. Pract. 2015, 5(3), 780; https://doi.org/10.4081/cp.2015.780
Submission received: 13 April 2015 / Revised: 20 July 2015 / Accepted: 31 July 2015 / Published: 28 September 2015

Abstract

Electroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to premature termination of ECT. Treatment of this cognitive impairment is of utmost importance. In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on cognitive impairment in three older, severely depressed patients during or after a course of ECT. An improvement of cognitive functioning, in particular a decline of confusional symptoms, was observed in two patients with structural brain alterations associated with aging. In the other patient, who suffered primarily from amnesia, no effect of rivastigmine was observed. These preliminary results emphasize the need for detailed profiling of cognitive impairment when developing a research design to study the potential benefits of rivastigmine in the prevention or treatment of cognitive impairment in severely depressed patients treated with ECT.
Keywords: depression; cognitive impairment; electroconvulsive therapy; elderly; acetylcholinesterase inhibitor; rivastigmine depression; cognitive impairment; electroconvulsive therapy; elderly; acetylcholinesterase inhibitor; rivastigmine

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MDPI and ACS Style

van Schaik, A.M.; Rhebergen, D.; Henstra, M.J.; Kadouch, D.J.; van Exel, E.; Stek, M.L. Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could Be the Role of Rivastigmine? A Case Series. Clin. Pract. 2015, 5, 780. https://doi.org/10.4081/cp.2015.780

AMA Style

van Schaik AM, Rhebergen D, Henstra MJ, Kadouch DJ, van Exel E, Stek ML. Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could Be the Role of Rivastigmine? A Case Series. Clinics and Practice. 2015; 5(3):780. https://doi.org/10.4081/cp.2015.780

Chicago/Turabian Style

van Schaik, Audrey Monica, Didi Rhebergen, Marieke Jantien Henstra, Daniel J. Kadouch, Eric van Exel, and Maximilianus Lourentius Stek. 2015. "Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could Be the Role of Rivastigmine? A Case Series" Clinics and Practice 5, no. 3: 780. https://doi.org/10.4081/cp.2015.780

APA Style

van Schaik, A. M., Rhebergen, D., Henstra, M. J., Kadouch, D. J., van Exel, E., & Stek, M. L. (2015). Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could Be the Role of Rivastigmine? A Case Series. Clinics and Practice, 5(3), 780. https://doi.org/10.4081/cp.2015.780

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