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Clinics and Practice
Volume 3
Issue 2
10.4081/cp.2013.e17
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Acute Steatohepatitis, Due to Extreme Metabolic Dysregulation, as the First Presentation of Non-Alcoholic Fatty Liver Disease

by
Georgios Kranidiotis
*,
Angeliki Angelidi
,
Emmanouel Sevdalis
,
Thomas-Nikolaos Telios
,
Alexandra Gougoutsi
and
Andreas Melidonis
1st Department of Internal Medicine, “Tzaneion” General Hospital, Piraeus, Greece
*
Author to whom correspondence should be addressed.
Clin. Pract. 2013, 3(2), e17; https://doi.org/10.4081/cp.2013.e17
Submission received: 22 December 2012 / Revised: 8 March 2013 / Accepted: 12 March 2013 / Published: 20 May 2013

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a slowly progressive chronic disease, with a high prevalence among obese, dyslipidemic or diabetic people, commonly presented as an asymptomatic mild elevation of serum aminotransferases. We report a patient who experienced an acute form of non-alcoholic steatohepatitis, as the first manifestation of NAFLD, due to exacerbation of pre-existing metabolic disorders by an extremely unhealthy lifestyle. A 50-year old, obese, diabetic man presented with a one-week history of jaundice and malaise. Analysis revealed elevated liver enzymes, bilirubin, lipids, and glucose. Based on patient’s history, physical examination, laboratory results, and imaging findings, acute non-alcoholic steatohepatitis was established as a diagnosis of exclusion. The patient was started on a low-calorie diet free of carbohydrates and fats, in combination with insulin. A dramatic improvement of clinical and laboratory parameters was observed. In the context of extreme metabolic dysregulation, induced by unhealthy diet, NAFLD may present as an acute steatohepatitis.
Keywords: non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity; diabetes mellitus non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity; diabetes mellitus

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MDPI and ACS Style

Kranidiotis, G.; Angelidi, A.; Sevdalis, E.; Telios, T.-N.; Gougoutsi, A.; Melidonis, A. Acute Steatohepatitis, Due to Extreme Metabolic Dysregulation, as the First Presentation of Non-Alcoholic Fatty Liver Disease. Clin. Pract. 2013, 3, e17. https://doi.org/10.4081/cp.2013.e17

AMA Style

Kranidiotis G, Angelidi A, Sevdalis E, Telios T-N, Gougoutsi A, Melidonis A. Acute Steatohepatitis, Due to Extreme Metabolic Dysregulation, as the First Presentation of Non-Alcoholic Fatty Liver Disease. Clinics and Practice. 2013; 3(2):e17. https://doi.org/10.4081/cp.2013.e17

Chicago/Turabian Style

Kranidiotis, Georgios, Angeliki Angelidi, Emmanouel Sevdalis, Thomas-Nikolaos Telios, Alexandra Gougoutsi, and Andreas Melidonis. 2013. "Acute Steatohepatitis, Due to Extreme Metabolic Dysregulation, as the First Presentation of Non-Alcoholic Fatty Liver Disease" Clinics and Practice 3, no. 2: e17. https://doi.org/10.4081/cp.2013.e17

APA Style

Kranidiotis, G., Angelidi, A., Sevdalis, E., Telios, T. -N., Gougoutsi, A., & Melidonis, A. (2013). Acute Steatohepatitis, Due to Extreme Metabolic Dysregulation, as the First Presentation of Non-Alcoholic Fatty Liver Disease. Clinics and Practice, 3(2), e17. https://doi.org/10.4081/cp.2013.e17

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